Leurs R - Search Results

1

Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.

Smits RA, Lim HD, Stegink B, Bakker RA, de Esch IJ, Leurs R. Smits RA, et al. Among authors: leurs r. J Med Chem. 2006 Jul 27;49(15):4512-6. doi: 10.1021/jm051008s. J Med Chem. 2006. PMID: 16854056

2

Histamine receptors: subclasses and specific ligands.

Haaksma EE, Leurs R, Timmerman H. Haaksma EE, et al. Among authors: leurs r. Pharmacol Ther. 1990;47(1):73-104. doi: 10.1016/0163-7258(90)90046-5. Pharmacol Ther. 1990. PMID: 2195558 Review.

3

High affinity, saturable [3H]mepyramine binding sites on rat liver plasma membrane do not represent histamine H1-receptors. A warning.

Leurs R, Bast A, Timmerman H. Leurs R, et al. Biochem Pharmacol. 1989 Jul 1;38(13):2175-80. doi: 10.1016/0006-2952(89)90073-7. Biochem Pharmacol. 1989. PMID: 2567596

4

Molecular pharmacological aspects of histamine receptors.

Leurs R, Smit MJ, Timmerman H. Leurs R, et al. Pharmacol Ther. 1995 Jun;66(3):413-63. doi: 10.1016/0163-7258(95)00006-3. Pharmacol Ther. 1995. PMID: 7494855 Review.

5

New analogs of burimamide as potent and selective histamine H3 receptor antagonists: the effect of chain length variation of the alkyl spacer and modifications of the N-thiourea substituent.

Vollinga RC, Menge WM, Leurs R, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1995 Jun 9;38(12):2244-50. doi: 10.1021/jm00012a025. J Med Chem. 1995. PMID: 7783156

6

Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.

Vollinga RC, Menge WM, Leurs R, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1995 Jan 20;38(2):266-71. doi: 10.1021/jm00002a008. J Med Chem. 1995. PMID: 7830269

7

A new potent and selective histamine H3 receptor agonist, 4-(1H-imidazol-4-ylmethyl)piperidine.

Vollinga RC, de Koning JP, Jansen FP, Leurs R, Menge WM, Timmerman H. Vollinga RC, et al. Among authors: leurs r. J Med Chem. 1994 Feb 4;37(3):332-3. doi: 10.1021/jm00029a002. J Med Chem. 1994. PMID: 8308858 No abstract available.

8

Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.

ter Laak AM, Timmerman H, Leurs R, Nederkoorn PH, Smit MJ, Donné-Op den Kelder GM. ter Laak AM, et al. Among authors: leurs r. J Comput Aided Mol Des. 1995 Aug;9(4):319-30. doi: 10.1007/BF00125173. J Comput Aided Mol Des. 1995. PMID: 8523041

9

Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists.

Smit MJ, Roovers E, Timmerman H, van de Vrede Y, Alewijnse AE, Leurs R. Smit MJ, et al. Among authors: leurs r. J Biol Chem. 1996 Mar 29;271(13):7574-82. doi: 10.1074/jbc.271.13.7574. J Biol Chem. 1996. PMID: 8631790 Free article.

10

Histamine homologues discriminating between two functional H3 receptor assays. Evidence for H3 receptor heterogeneity?

Leurs R, Kathmann M, Vollinga RC, Menge WM, Schlicker E, Timmerman H. Leurs R, et al. J Pharmacol Exp Ther. 1996 Mar;276(3):1009-15. J Pharmacol Exp Ther. 1996. PMID: 8786529

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