Bertoncini CW - Search Results

1

Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement.

Binolfi A, Rasia RM, Bertoncini CW, Ceolin M, Zweckstetter M, Griesinger C, Jovin TM, Fernández CO. Binolfi A, et al. Among authors: bertoncini cw. J Am Chem Soc. 2006 Aug 2;128(30):9893-901. doi: 10.1021/ja0618649. J Am Chem Soc. 2006. PMID: 16866548

2

Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings.

Bernadó P, Bertoncini CW, Griesinger C, Zweckstetter M, Blackledge M. Bernadó P, et al. Among authors: bertoncini cw. J Am Chem Soc. 2005 Dec 28;127(51):17968-9. doi: 10.1021/ja055538p. J Am Chem Soc. 2005. PMID: 16366524

3

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation.

Binolfi A, Lamberto GR, Duran R, Quintanar L, Bertoncini CW, Souza JM, Cerveñansky C, Zweckstetter M, Griesinger C, Fernández CO. Binolfi A, et al. Among authors: bertoncini cw. J Am Chem Soc. 2008 Sep 3;130(35):11801-12. doi: 10.1021/ja803494v. Epub 2008 Aug 9. J Am Chem Soc. 2008. PMID: 18693689

4

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation.

Lamberto GR, Binolfi A, Orcellet ML, Bertoncini CW, Zweckstetter M, Griesinger C, Fernández CO. Lamberto GR, et al. Among authors: bertoncini cw. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21057-62. doi: 10.1073/pnas.0902603106. Epub 2009 Nov 30. Proc Natl Acad Sci U S A. 2009. PMID: 19948969 Free PMC article.

5

Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.

Lamberto GR, Torres-Monserrat V, Bertoncini CW, Salvatella X, Zweckstetter M, Griesinger C, Fernández CO. Lamberto GR, et al. Among authors: bertoncini cw. J Biol Chem. 2011 Sep 16;286(37):32036-44. doi: 10.1074/jbc.M111.242958. Epub 2011 Jul 27. J Biol Chem. 2011. PMID: 21795682 Free PMC article.

6

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein.

Bertoncini CW, Jung YS, Fernandez CO, Hoyer W, Griesinger C, Jovin TM, Zweckstetter M. Bertoncini CW, et al. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1430-5. doi: 10.1073/pnas.0407146102. Epub 2005 Jan 25. Proc Natl Acad Sci U S A. 2005. PMID: 15671169 Free PMC article.

7

Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.

Rasia RM, Bertoncini CW, Marsh D, Hoyer W, Cherny D, Zweckstetter M, Griesinger C, Jovin TM, Fernández CO. Rasia RM, et al. Among authors: bertoncini cw. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4294-9. doi: 10.1073/pnas.0407881102. Epub 2005 Mar 14. Proc Natl Acad Sci U S A. 2005. PMID: 15767574 Free PMC article.

8

Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation.

Bertoncini CW, Fernandez CO, Griesinger C, Jovin TM, Zweckstetter M. Bertoncini CW, et al. J Biol Chem. 2005 Sep 2;280(35):30649-52. doi: 10.1074/jbc.C500288200. Epub 2005 Jul 14. J Biol Chem. 2005. PMID: 16020550 Free article.

9

Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation.

Bertoncini CW, Rasia RM, Lamberto GR, Binolfi A, Zweckstetter M, Griesinger C, Fernandez CO. Bertoncini CW, et al. J Mol Biol. 2007 Sep 21;372(3):708-22. doi: 10.1016/j.jmb.2007.07.009. Epub 2007 Jul 17. J Mol Biol. 2007. PMID: 17681539

10

Changes in interfacial properties of alpha-synuclein preceding its aggregation.

Palecek E, Ostatná V, Masarík M, Bertoncini CW, Jovin TM. Palecek E, et al. Among authors: bertoncini cw. Analyst. 2008 Jan;133(1):76-84. doi: 10.1039/b712812f. Epub 2007 Oct 15. Analyst. 2008. PMID: 18087617

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