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Catalytic site mutations confer multiple states of G protein activation.
Hewitt N, Ma N, Arang N, Martin SA, Prakash A, DiBerto JF, Knight KM, Ghosh S, Olsen RHJ, Roth BL, Gutkind JS, Vaidehi N, Campbell SL, Dohlman HG. Hewitt N, et al. Among authors: vaidehi n. Sci Signal. 2023 Feb 14;16(772):eabq7842. doi: 10.1126/scisignal.abq7842. Epub 2023 Feb 14. Sci Signal. 2023. PMID: 36787384 Free PMC article.
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state.
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG. Knight KM, et al. Among authors: vaidehi n. Nat Commun. 2024 Aug 5;15(1):6643. doi: 10.1038/s41467-024-50964-z. Nat Commun. 2024. PMID: 39103320 Free PMC article.
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery.
Chan AKN, Han L, Delaney CD, Wang X, Mukhaleva E, Li M, Yang L, Pokharel SP, Mattson N, Garcia M, Wang B, Xu X, Zhang L, Singh P, Elsayed Z, Chen R, Kuang B, Wang J, Yuan YC, Chen B, Chan LN, Rosen ST, Horne D, Müschen M, Chen J, Vaidehi N, Armstrong SA, Su R, Chen CW. Chan AKN, et al. Among authors: vaidehi n. Sci Adv. 2024 Feb 23;10(8):eadk3127. doi: 10.1126/sciadv.adk3127. Epub 2024 Feb 23. Sci Adv. 2024. PMID: 38394203 Free PMC article.
Cellular Lipids Regulate the Conformational Ensembles of the Disordered Intracellular Loop 3 in β2 Adrenergic Receptor.
Mukhaleva E, Yang T, Sadler F, Sivaramakrishnan S, Ma N, Vaidehi N. Mukhaleva E, et al. Among authors: vaidehi n. bioRxiv [Preprint]. 2023 Nov 29:2023.11.28.569080. doi: 10.1101/2023.11.28.569080. bioRxiv. 2023. Update in: iScience. 2024 May 23;27(6):110086. doi: 10.1016/j.isci.2024.110086 PMID: 38077083 Free PMC article. Updated. Preprint.
148 results