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EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant.
van Empel VP, Bertrand AT, van Oort RJ, van der Nagel R, Engelen M, van Rijen HV, Doevendans PA, Crijns HJ, Ackerman SL, Sluiter W, De Windt LJ. van Empel VP, et al. Among authors: van rijen hv, van der nagel r, van oort rj. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32. doi: 10.1016/j.jacc.2006.02.075. Epub 2006 Jul 25. J Am Coll Cardiol. 2006. PMID: 16904556 Free article.
Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation.
van Empel VP, Bertrand AT, van der Nagel R, Kostin S, Doevendans PA, Crijns HJ, de Wit E, Sluiter W, Ackerman SL, De Windt LJ. van Empel VP, et al. Among authors: van der nagel r. Circ Res. 2005 Jun 24;96(12):e92-e101. doi: 10.1161/01.RES.0000172081.30327.28. Epub 2005 Jun 2. Circ Res. 2005. PMID: 15933268
MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure.
van Oort RJ, van Rooij E, Bourajjaj M, Schimmel J, Jansen MA, van der Nagel R, Doevendans PA, Schneider MD, van Echteld CJ, De Windt LJ. van Oort RJ, et al. Among authors: van rooij e, van echteld cj, van der nagel r. Circulation. 2006 Jul 25;114(4):298-308. doi: 10.1161/CIRCULATIONAHA.105.608968. Epub 2006 Jul 17. Circulation. 2006. PMID: 16847152
In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms.
Bierhuizen MF, Boulaksil M, van Stuijvenberg L, van der Nagel R, Jansen AT, Mutsaers NA, Yildirim C, van Veen TA, de Windt LJ, Vos MA, van Rijen HV. Bierhuizen MF, et al. Among authors: van rijen hv, van stuijvenberg l, van der nagel r, van veen ta. J Mol Cell Cardiol. 2008 Sep;45(3):373-84. doi: 10.1016/j.yjmcc.2008.06.011. Epub 2008 Jul 11. J Mol Cell Cardiol. 2008. PMID: 18662696
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.
da Costa Martins PA, Salic K, Gladka MM, Armand AS, Leptidis S, el Azzouzi H, Hansen A, Coenen-de Roo CJ, Bierhuizen MF, van der Nagel R, van Kuik J, de Weger R, de Bruin A, Condorelli G, Arbones ML, Eschenhagen T, De Windt LJ. da Costa Martins PA, et al. Among authors: van kuik j, van der nagel r. Nat Cell Biol. 2010 Dec;12(12):1220-7. doi: 10.1038/ncb2126. Epub 2010 Nov 21. Nat Cell Biol. 2010. PMID: 21102440
Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection.
el Azzouzi H, Leptidis S, Bourajjaj M, Armand AS, van der Nagel R, van Bilsen M, Da Costa Martins PA, De Windt LJ. el Azzouzi H, et al. Among authors: van bilsen m, van der nagel r. J Biol Chem. 2011 Apr 22;286(16):14598-607. doi: 10.1074/jbc.M111.220525. Epub 2011 Jan 18. J Biol Chem. 2011. PMID: 21245137 Free PMC article.
Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity.
Jansen JA, van Veen TA, de Jong S, van der Nagel R, van Stuijvenberg L, Driessen H, Labzowski R, Oefner CM, Bosch AA, Nguyen TQ, Goldschmeding R, Vos MA, de Bakker JM, van Rijen HV. Jansen JA, et al. Among authors: van rijen hv, van stuijvenberg l, van der nagel r, van veen ta. Circ Arrhythm Electrophysiol. 2012 Apr;5(2):380-90. doi: 10.1161/CIRCEP.111.966580. Epub 2012 Feb 24. Circ Arrhythm Electrophysiol. 2012. PMID: 22368123
31 results