Pähler A - Search Results

1

Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.

Alvarez-Sanchez R, Montavon F, Hartung T, Pähler A. Alvarez-Sanchez R, et al. Among authors: pahler a. Chem Res Toxicol. 2006 Aug;19(8):1106-16. doi: 10.1021/tx050353h. Chem Res Toxicol. 2006. PMID: 16918252

2

A targeted proteomics approach to the identification of peptides modified by reactive metabolites.

Tzouros M, Pähler A. Tzouros M, et al. Among authors: pahler a. Chem Res Toxicol. 2009 May;22(5):853-62. doi: 10.1021/tx800426x. Chem Res Toxicol. 2009. PMID: 19317514

3

Glutathione conjugates of 4-hydroxy-2(E)-nonenal as biomarkers of hepatic oxidative stress-induced lipid peroxidation in rats.

Völkel W, Alvarez-Sánchez R, Weick I, Mally A, Dekant W, Pähler A. Völkel W, et al. Among authors: pahler a. Free Radic Biol Med. 2005 Jun 1;38(11):1526-36. doi: 10.1016/j.freeradbiomed.2005.02.015. Free Radic Biol Med. 2005. PMID: 15890627

4

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, Honer M, Huwyler J, Kuratli M, Niederhauser U, Pähler A, Peters JU, Petersen A, Prinssen E, Ricci A, Rueher D, Rueher M, Schneider M, Spurr P, Stoll T, Tännler D, Wichmann J, Porter RH, Wettstein JG, Lindemann L. Jaeschke G, et al. Among authors: pahler a. J Med Chem. 2015 Feb 12;58(3):1358-71. doi: 10.1021/jm501642c. Epub 2015 Feb 2. J Med Chem. 2015. PMID: 25565255

5

Determination of dalcetrapib by liquid chromatography-tandem mass spectrometry.

Heinig K, Bucheli F, Kuhlmann O, Zell M, Pähler A, Zwanziger E, Gross G, Tardio J, Ishikawa T, Yamashita T. Heinig K, et al. Among authors: pahler a. J Pharm Biomed Anal. 2012 Jul;66:314-24. doi: 10.1016/j.jpba.2012.03.056. Epub 2012 Apr 6. J Pharm Biomed Anal. 2012. PMID: 22541249

6

Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates.

Brink A, Fontaine F, Marschmann M, Steinhuber B, Cece EN, Zamora I, Pähler A. Brink A, et al. Among authors: pahler a. Rapid Commun Mass Spectrom. 2014 Dec 30;28(24):2695-703. doi: 10.1002/rcm.7062. Rapid Commun Mass Spectrom. 2014. PMID: 25380491

7

Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction - Liquid chromatography-tandem mass spectrometry.

Teppner M, Zell M, Husser C, Ernst B, Pähler A. Teppner M, et al. Among authors: pahler a. Anal Biochem. 2016 Apr 1;498:68-77. doi: 10.1016/j.ab.2016.01.005. Epub 2016 Jan 22. Anal Biochem. 2016. PMID: 26808647

8

In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human.

Lavé T, Birnböck H, Götschi A, Ramp T, Pähler A. Lavé T, et al. Among authors: pahler a. Toxicol Lett. 2009 Nov 12;190(3):303-9. doi: 10.1016/j.toxlet.2009.07.030. Epub 2009 Aug 18. Toxicol Lett. 2009. PMID: 19695315

9

Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.

Husser C, Pähler A, Seymour M, Kuhlmann O, Schadt S, Zell M. Husser C, et al. Among authors: pahler a. J Pharm Biomed Anal. 2018 Apr 15;152:143-154. doi: 10.1016/j.jpba.2018.01.022. Epub 2018 Jan 12. J Pharm Biomed Anal. 2018. PMID: 29414006

10

Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery.

Cece-Esencan EN, Fontaine F, Plasencia G, Teppner M, Brink A, Pähler A, Zamora I. Cece-Esencan EN, et al. Among authors: pahler a. Rapid Commun Mass Spectrom. 2016 Jan 30;30(2):301-10. doi: 10.1002/rcm.7429. Rapid Commun Mass Spectrom. 2016. PMID: 26689160

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