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Page 1
Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors.
Noronha G, Barrett K, Cao J, Dneprovskaia E, Fine R, Gong X, Gritzen C, Hood J, Kang X, Klebansky B, Li G, Liao W, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Soll R, Splittgerber U, Wrasidlo W, Zeng B, Zhao N, Zhou Y. Noronha G, et al. Among authors: pathak vp. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5546-50. doi: 10.1016/j.bmcl.2006.08.035. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931012
Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.
Noronha G, Barrett K, Boccia A, Brodhag T, Cao J, Chow CP, Dneprovskaia E, Doukas J, Fine R, Gong X, Gritzen C, Gu H, Hanna E, Hood JD, Hu S, Kang X, Key J, Klebansky B, Kousba A, Li G, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Shi F, Soll R, Splittgerber U, Stoughton S, Tang S, Yee S, Zeng B, Zhao N, Zhu H. Noronha G, et al. Among authors: pathak vp. Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. doi: 10.1016/j.bmcl.2006.11.006. Epub 2006 Nov 7. Bioorg Med Chem Lett. 2007. PMID: 17113292
The design and preliminary structure-activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes.
Cao J, Fine R, Gritzen C, Hood J, Kang X, Klebansky B, Lohse D, Mak CC, McPherson A, Noronha G, Palanki MS, Pathak VP, Renick J, Soll R, Zeng B, Zhu H. Cao J, et al. Among authors: pathak vp. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5812-8. doi: 10.1016/j.bmcl.2007.08.043. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2007. PMID: 17827012
Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.
Palanki MS, Akiyama H, Campochiaro P, Cao J, Chow CP, Dellamary L, Doukas J, Fine R, Gritzen C, Hood JD, Hu S, Kachi S, Kang X, Klebansky B, Kousba A, Lohse D, Mak CC, Martin M, McPherson A, Pathak VP, Renick J, Soll R, Umeda N, Yee S, Yokoi K, Zeng B, Zhu H, Noronha G. Palanki MS, et al. Among authors: pathak vp. J Med Chem. 2008 Mar 27;51(6):1546-59. doi: 10.1021/jm7011276. Epub 2008 Feb 27. J Med Chem. 2008. PMID: 18311895
Inhibitors of ABL and the ABL-T315I mutation.
Noronha G, Cao J, Chow CP, Dneprovskaia E, Fine RM, Hood J, Kang X, Klebansky B, Lohse D, Mak CC, McPherson A, Palanki MS, Pathak VP, Renick J, Soll R, Zeng B. Noronha G, et al. Among authors: pathak vp. Curr Top Med Chem. 2008;8(10):905-21. doi: 10.2174/156802608784911635. Curr Top Med Chem. 2008. PMID: 18673174
Development of novel benzotriazines for drug discovery.
Palanki MS, Cao J, Chow CP, Dneprovskaia E, Mak CC, McPherson A, Pathak VP, Renick J, Soll R, Zeng B, Noronha G. Palanki MS, et al. Among authors: pathak vp. Expert Opin Drug Discov. 2009 Jan;4(1):33-49. doi: 10.1517/17460440802580536. Epub 2008 Dec 10. Expert Opin Drug Discov. 2009. PMID: 23480335
Structure-based design of novel human Pin1 inhibitors (II).
Dong L, Marakovits J, Hou X, Guo C, Greasley S, Dagostino E, Ferre R, Johnson MC, Kraynov E, Thomson J, Pathak V, Murray BW. Dong L, et al. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. doi: 10.1016/j.bmcl.2010.02.033. Epub 2010 Feb 14. Bioorg Med Chem Lett. 2010. PMID: 20207139
Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats.
Anderes KL, Luthin DR, Castillo R, Kraynov EA, Castro M, Nared-Hood K, Gregory ML, Pathak VP, Christie LC, Paderes G, Vazir H, Ye Q, Anderson MB, May JM. Anderes KL, et al. Among authors: pathak vp. J Pharmacol Exp Ther. 2003 May;305(2):688-95. doi: 10.1124/jpet.102.046656. Epub 2003 Jan 24. J Pharmacol Exp Ther. 2003. PMID: 12606616
42 results