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5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, Leeson P, Neubauer S, Ratnatunga C, Pillai R, Refsum H, Channon KM. Antoniades C, et al. Among authors: ratnatunga c. Circulation. 2006 Sep 12;114(11):1193-201. doi: 10.1161/CIRCULATIONAHA.106.612325. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940192 Clinical Trial.
Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.
Shirodaria C, Antoniades C, Lee J, Jackson CE, Robson MD, Francis JM, Moat SJ, Ratnatunga C, Pillai R, Refsum H, Neubauer S, Channon KM. Shirodaria C, et al. Among authors: ratnatunga c. Circulation. 2007 May 1;115(17):2262-70. doi: 10.1161/CIRCULATIONAHA.106.679084. Epub 2007 Apr 9. Circulation. 2007. PMID: 17420345 Clinical Trial.
Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
Antoniades C, Shirodaria C, Crabtree M, Rinze R, Alp N, Cunnington C, Diesch J, Tousoulis D, Stefanadis C, Leeson P, Ratnatunga C, Pillai R, Channon KM. Antoniades C, et al. Among authors: ratnatunga c. Circulation. 2007 Dec 11;116(24):2851-9. doi: 10.1161/CIRCULATIONAHA.107.704155. Epub 2007 Nov 26. Circulation. 2007. PMID: 18040031
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
Antoniades C, Shirodaria C, Leeson P, Antonopoulos A, Warrick N, Van-Assche T, Cunnington C, Tousoulis D, Pillai R, Ratnatunga C, Stefanadis C, Channon KM. Antoniades C, et al. Among authors: ratnatunga c. Eur Heart J. 2009 May;30(9):1142-50. doi: 10.1093/eurheartj/ehp061. Epub 2009 Mar 18. Eur Heart J. 2009. PMID: 19297385
MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis.
Antoniades C, Shirodaria C, Leeson P, Baarholm OA, Van-Assche T, Cunnington C, Pillai R, Ratnatunga C, Tousoulis D, Stefanadis C, Refsum H, Channon KM. Antoniades C, et al. Among authors: ratnatunga c. Circulation. 2009 May 12;119(18):2507-15. doi: 10.1161/CIRCULATIONAHA.108.808675. Epub 2009 Apr 27. Circulation. 2009. PMID: 19398669
Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
Cunnington C, Van Assche T, Shirodaria C, Kylintireas I, Lindsay AC, Lee JM, Antoniades C, Margaritis M, Lee R, Cerrato R, Crabtree MJ, Francis JM, Sayeed R, Ratnatunga C, Pillai R, Choudhury RP, Neubauer S, Channon KM. Cunnington C, et al. Among authors: ratnatunga c. Circulation. 2012 Mar 20;125(11):1356-66. doi: 10.1161/CIRCULATIONAHA.111.038919. Epub 2012 Feb 7. Circulation. 2012. PMID: 22315282 Free PMC article. Clinical Trial.
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