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Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.
Mo H, Lu L, Pilot-Matias T, Pithawalla R, Mondal R, Masse S, Dekhtyar T, Ng T, Koev G, Stoll V, Stewart KD, Pratt J, Donner P, Rockway T, Maring C, Molla A. Mo H, et al. Among authors: dekhtyar t. Antimicrob Agents Chemother. 2005 Oct;49(10):4305-14. doi: 10.1128/AAC.49.10.4305-4314.2005. Antimicrob Agents Chemother. 2005. PMID: 16189112 Free PMC article.
A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations.
Middleton T, He Y, Pilot-Matias T, Tripathi R, Lim BH, Roth A, Chen CM, Koev G, Ng TI, Krishnan P, Pithawalla R, Mondal R, Dekhtyar T, Lu L, Mo H, Kati WM, Molla A. Middleton T, et al. Among authors: dekhtyar t. J Virol Methods. 2007 Nov;145(2):137-45. doi: 10.1016/j.jviromet.2007.05.016. Epub 2007 Jun 29. J Virol Methods. 2007. PMID: 17604129
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.
Randolph JT, Huang PP, Flosi WJ, DeGoey D, Klein LL, Yeung CM, Flentge C, Sun M, Zhao C, Dekhtyar T, Mo H, Colletti L, Kati W, Marsh KC, Molla A, Kempf DJ. Randolph JT, et al. Among authors: dekhtyar t. Bioorg Med Chem. 2006 Jun 15;14(12):4035-46. doi: 10.1016/j.bmc.2006.02.013. Epub 2006 Feb 28. Bioorg Med Chem. 2006. PMID: 16504523
Identification and structural characterization of I84C and I84A mutations that are associated with high-level resistance to human immunodeficiency virus protease inhibitors and impair viral replication.
Mo H, Parkin N, Stewart KD, Lu L, Dekhtyar T, Kempf DJ, Molla A. Mo H, et al. Among authors: dekhtyar t. Antimicrob Agents Chemother. 2007 Feb;51(2):732-5. doi: 10.1128/AAC.00690-06. Epub 2006 Nov 13. Antimicrob Agents Chemother. 2007. PMID: 17101675 Free PMC article.
In vitro and in vivo antiviral activity and resistance profile of the hepatitis C virus NS3/4A protease inhibitor ABT-450.
Pilot-Matias T, Tripathi R, Cohen D, Gaultier I, Dekhtyar T, Lu L, Reisch T, Irvin M, Hopkins T, Pithawalla R, Middleton T, Ng T, McDaniel K, Or YS, Menon R, Kempf D, Molla A, Collins C. Pilot-Matias T, et al. Among authors: dekhtyar t. Antimicrob Agents Chemother. 2015 Feb;59(2):988-97. doi: 10.1128/AAC.04227-14. Epub 2014 Dec 1. Antimicrob Agents Chemother. 2015. PMID: 25451053 Free PMC article. Clinical Trial.
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