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Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M. Itoh N, et al. Among authors: takemoto h. Neurodegener Dis. 2009;6(5-6):230-9. doi: 10.1159/000236902. Epub 2009 Sep 9. Neurodegener Dis. 2009. PMID: 19738368
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Yonezawa S, Yamakawa H, Muto C, Hosono M, Yamamoto T, Hattori K, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: takemoto h. Bioorg Med Chem Lett. 2013 May 15;23(10):2912-5. doi: 10.1016/j.bmcl.2013.03.056. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23562056
Conformational restriction approach to β-secretase (BACE1) inhibitors III: effective investigation of the binding mode by combinational use of X-ray analysis, isothermal titration calorimetry and theoretical calculations.
Yonezawa S, Fujiwara K, Yamamoto T, Hattori K, Yamakawa H, Muto C, Hosono M, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: takemoto h. Bioorg Med Chem. 2013 Nov 1;21(21):6506-22. doi: 10.1016/j.bmc.2013.08.036. Epub 2013 Aug 28. Bioorg Med Chem. 2013. PMID: 24051074
Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: takemoto h. J Med Chem. 2012 Oct 25;55(20):8838-58. doi: 10.1021/jm3011405. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998419
Expansion of Antibacterial Spectrum of Muraymycins toward Pseudomonas aeruginosa.
Takeoka Y, Tanino T, Sekiguchi M, Yonezawa S, Sakagami M, Takahashi F, Togame H, Tanaka Y, Takemoto H, Ichikawa S, Matsuda A. Takeoka Y, et al. Among authors: takemoto h. ACS Med Chem Lett. 2014 Mar 6;5(5):556-60. doi: 10.1021/ml5000096. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900879 Free PMC article.
Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.
Arioka S, Sakagami M, Uematsu R, Yamaguchi H, Togame H, Takemoto H, Hinou H, Nishimura S. Arioka S, et al. Among authors: takemoto h. Bioorg Med Chem. 2010 Feb 15;18(4):1633-40. doi: 10.1016/j.bmc.2009.12.062. Epub 2010 Jan 6. Bioorg Med Chem. 2010. PMID: 20097567
318 results