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Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.
Hashimoto M, Takada Y, Takeuchi Y, Kasahara J, Hisa H, Shirasaki Y, Fukunaga K. Hashimoto M, et al. Among authors: shirasaki y. J Pharmacol Sci. 2005 Jun;98(2):142-50. doi: 10.1254/jphs.fp0040551. Epub 2005 Jun 4. J Pharmacol Sci. 2005. PMID: 15937403 Free article.
3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydro-chloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: role of the cross-talk between calpain and caspase-3 through calpastatin.
Han F, Shirasaki Y, Fukunaga K. Han F, et al. Among authors: shirasaki y. J Pharmacol Exp Ther. 2006 May;317(2):529-36. doi: 10.1124/jpet.105.095018. Epub 2006 Feb 8. J Pharmacol Exp Ther. 2006. PMID: 16467455
Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled endothelial nitric-oxide synthase and ameliorated by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a novel calmodulin antagonist.
Lu YM, Han F, Shioda N, Moriguchi S, Shirasaki Y, Qin ZH, Fukunaga K. Lu YM, et al. Among authors: shirasaki y. Mol Pharmacol. 2009 Jan;75(1):101-12. doi: 10.1124/mol.108.050716. Epub 2008 Oct 24. Mol Pharmacol. 2009. PMID: 18952768
The post-ischemic administration of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, prevents delayed neuronal death in gerbil hippocampus.
Hashiguchi A, Yano S, Morioka M, Hamada J, Shirasaki Y, Kochi M, Fukunaga K. Hashiguchi A, et al. Among authors: shirasaki y. J Pharmacol Sci. 2004 Sep;96(1):65-72. doi: 10.1254/jphs.fp0040348. Epub 2004 Sep 10. J Pharmacol Sci. 2004. PMID: 15359085 Free article.
156 results