Cavender D - Search Results

1

Inhibitors of unactivated p38 MAP kinase.

Bullington J, Argentieri D, Averill K, Carter D, Cavender D, Fahmy B, Fan X, Hall D, Heintzelman G, Jackson P, Leung WP, Li X, Ling P, Olini G, Razler T, Reuman M, Rupert K, Russell R, Siekierka J, Wadsworth S, Wolff R, Xiang B, Zhang YM. Bullington J, et al. Among authors: cavender d. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6102-6. doi: 10.1016/j.bmcl.2006.08.101. Epub 2006 Sep 12. Bioorg Med Chem Lett. 2006. PMID: 16971122

2

Imidazopyrimidines, potent inhibitors of p38 MAP kinase.

Rupert KC, Henry JR, Dodd JH, Wadsworth SA, Cavender DE, Olini GC, Fahmy B, Siekierka JJ. Rupert KC, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50. doi: 10.1016/s0960-894x(02)01020-x. Bioorg Med Chem Lett. 2003. PMID: 12565927

3

6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor.

Henry JR, Rupert KC, Dodd JH, Turchi IJ, Wadsworth SA, Cavender DE, Fahmy B, Olini GC, Davis JE, Pellegrino-Gensey JL, Schafer PH, Siekierka JJ. Henry JR, et al. Among authors: cavender de. J Med Chem. 1998 Oct 22;41(22):4196-8. doi: 10.1021/jm980497b. J Med Chem. 1998. PMID: 9784093 No abstract available.

4

Potent inhibitors of the MAP kinase p38.

Henry JR, Rupert KC, Dodd JH, Turchi IJ, Wadsworth SA, Cavender DE, Schafer PH, Siekierka JJ. Henry JR, et al. Among authors: cavender de. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3335-40. doi: 10.1016/s0960-894x(98)00589-7. Bioorg Med Chem Lett. 1998. PMID: 9873730

5

RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

Wadsworth SA, Cavender DE, Beers SA, Lalan P, Schafer PH, Malloy EA, Wu W, Fahmy B, Olini GC, Davis JE, Pellegrino-Gensey JL, Wachter MP, Siekierka JJ. Wadsworth SA, et al. Among authors: cavender de. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7. J Pharmacol Exp Ther. 1999. PMID: 10525088

6

Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45.

Beers SA, Malloy EA, Wu W, Wachter MP, Gunnia U, Cavender D, Harris C, Davis J, Brosius R, Pellegrino-Gensey JL, Siekierka J. Beers SA, et al. Among authors: cavender d. Bioorg Med Chem. 1997 Dec;5(12):2203-11. doi: 10.1016/s0968-0896(97)00174-0. Bioorg Med Chem. 1997. PMID: 9459018

7

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production.

Kanakaraj P, Schafer PH, Cavender DE, Wu Y, Ngo K, Grealish PF, Wadsworth SA, Peterson PA, Siekierka JJ, Harris CA, Fung-Leung WP. Kanakaraj P, et al. Among authors: cavender de. J Exp Med. 1998 Jun 15;187(12):2073-9. doi: 10.1084/jem.187.12.2073. J Exp Med. 1998. PMID: 9625767 Free PMC article.

8

In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions.

Hou C, Kirchner T, Singer M, Matheis M, Argentieri D, Cavender D. Hou C, et al. Among authors: cavender d. J Pharmacol Exp Ther. 2004 May;309(2):697-704. doi: 10.1124/jpet.103.060574. Epub 2004 Jan 16. J Pharmacol Exp Ther. 2004. PMID: 14730005

9

Simplified staurosporine analogs as potent JAK3 inhibitors.

Yang SM, Malaviya R, Wilson LJ, Argentieri R, Chen X, Yang C, Wang B, Cavender D, Murray WV. Yang SM, et al. Among authors: cavender d. Bioorg Med Chem Lett. 2007 Jan 15;17(2):326-31. doi: 10.1016/j.bmcl.2006.10.062. Epub 2006 Oct 26. Bioorg Med Chem Lett. 2007. PMID: 17088059

10

Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.

Wilson LJ, Malaviya R, Yang C, Argentieri R, Wang B, Chen X, Murray WV, Cavender D. Wilson LJ, et al. Among authors: cavender d. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3333-8. doi: 10.1016/j.bmcl.2009.04.039. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19427203

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