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49 results

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Page 1
Discovery and design of benzimidazolone based inhibitors of p38 MAP kinase.
Hammach A, Barbosa A, Gaenzler FC, Fadra T, Goldberg D, Hao MH, Kroe RR, Liu P, Qian KC, Ralph M, Sarko C, Soleymanzadeh F, Moss N. Hammach A, et al. Among authors: hao mh. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6316-20. doi: 10.1016/j.bmcl.2006.09.014. Epub 2006 Sep 28. Bioorg Med Chem Lett. 2006. PMID: 17010605
Discovery and optimization of p38 inhibitors via computer-assisted drug design.
Goldberg DR, Hao MH, Qian KC, Swinamer AD, Gao DA, Xiong Z, Sarko C, Berry A, Lord J, Magolda RL, Fadra T, Kroe RR, Kukulka A, Madwed JB, Martin L, Pargellis C, Skow D, Song JJ, Tan Z, Torcellini CA, Zimmitti CS, Yee NK, Moss N. Goldberg DR, et al. Among authors: hao mh. J Med Chem. 2007 Aug 23;50(17):4016-26. doi: 10.1021/jm070415w. Epub 2007 Jul 20. J Med Chem. 2007. PMID: 17658737
Synthesis and SAR studies of indole-based MK2 inhibitors.
Xiong Z, Gao DA, Cogan DA, Goldberg DR, Hao MH, Moss N, Pack E, Pargellis C, Skow D, Trieselmann T, Werneburg B, White A. Xiong Z, et al. Among authors: hao mh. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1994-9. doi: 10.1016/j.bmcl.2008.01.119. Epub 2008 Feb 6. Bioorg Med Chem Lett. 2008. PMID: 18291646
Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region.
Lo HY, Nemoto PA, Kim JM, Hao MH, Qian KC, Farrow NA, Albaugh DR, Fowler DM, Schneiderman RD, Michael August E, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H, De Lombaert S. Lo HY, et al. Among authors: hao mh. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4533-9. doi: 10.1016/j.bmcl.2011.05.126. Epub 2011 Jun 17. Bioorg Med Chem Lett. 2011. PMID: 21733690
Pyrazinoindolone inhibitors of MAPKAP-K2.
Goldberg DR, Choi Y, Cogan D, Corson M, DeLeon R, Gao A, Gruenbaum L, Hao MH, Joseph D, Kashem MA, Miller C, Moss N, Netherton MR, Pargellis CP, Pelletier J, Sellati R, Skow D, Torcellini C, Tseng YC, Wang J, Wasti R, Werneburg B, Wu JP, Xiong Z. Goldberg DR, et al. Among authors: hao mh. Bioorg Med Chem Lett. 2008 Feb 1;18(3):938-41. doi: 10.1016/j.bmcl.2007.12.037. Epub 2007 Dec 23. Bioorg Med Chem Lett. 2008. PMID: 18221871
The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Wu JP, Fleck R, Brickwood J, Capolino A, Catron K, Chen Z, Cywin C, Emeigh J, Foerst M, Ginn J, Hrapchak M, Hickey E, Hao MH, Kashem M, Li J, Liu W, Morwick T, Nelson R, Marshall D, Martin L, Nemoto P, Potocki I, Liuzzi M, Peet GW, Scouten E, Stefany D, Turner M, Weldon S, Zimmitti C, Spero D, Kelly TA. Wu JP, et al. Among authors: hao mh. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5547-51. doi: 10.1016/j.bmcl.2009.08.054. Epub 2009 Aug 15. Bioorg Med Chem Lett. 2009. PMID: 19716697
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors.
Bekkali Y, Thomson DS, Betageri R, Emmanuel MJ, Hao MH, Hickey E, Liu W, Patel U, Ward YD, Young ER, Nelson R, Kukulka A, Brown ML, Crane K, White D, Freeman DM, Labadia ME, Wildeson J, Spero DM. Bekkali Y, et al. Among authors: hao mh. Bioorg Med Chem Lett. 2007 May 1;17(9):2465-9. doi: 10.1016/j.bmcl.2007.02.046. Epub 2007 Feb 23. Bioorg Med Chem Lett. 2007. PMID: 17379516
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors.
Ward YD, Thomson DS, Frye LL, Cywin CL, Morwick T, Emmanuel MJ, Zindell R, McNeil D, Bekkali Y, Girardot M, Hrapchak M, DeTuri M, Crane K, White D, Pav S, Wang Y, Hao MH, Grygon CA, Labadia ME, Freeman DM, Davidson W, Hopkins JL, Brown ML, Spero DM. Ward YD, et al. Among authors: hao mh. J Med Chem. 2002 Dec 5;45(25):5471-82. doi: 10.1021/jm020209i. J Med Chem. 2002. PMID: 12459015
Discovery of potent, selective chymase inhibitors via fragment linking strategies.
Taylor SJ, Padyana AK, Abeywardane A, Liang S, Hao MH, De Lombaert S, Proudfoot J, Farmer BS 3rd, Li X, Collins B, Martin L, Albaugh DR, Hill-Drzewi M, Pullen SS, Takahashi H. Taylor SJ, et al. Among authors: hao mh. J Med Chem. 2013 Jun 13;56(11):4465-81. doi: 10.1021/jm400138z. Epub 2013 Jun 4. J Med Chem. 2013. PMID: 23659209
49 results