Chiosis G - Search Results

1

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.

Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR. Hieronymus H, et al. Among authors: chiosis g. Cancer Cell. 2006 Oct;10(4):321-30. doi: 10.1016/j.ccr.2006.09.005. Epub 2006 Sep 28. Cancer Cell. 2006. PMID: 17010675 Free article.

2

Emerging Hsp90 inhibitors: from discovery to clinic.

Chiosis G, Rodina A, Moulick K. Chiosis G, et al. Anticancer Agents Med Chem. 2006 Jan;6(1):1-8. doi: 10.2174/187152006774755483. Anticancer Agents Med Chem. 2006. PMID: 16475922 Review.

3

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Moulick K, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. doi: 10.1016/j.bmcl.2006.06.025. Epub 2006 Jun 22. Bioorg Med Chem Lett. 2006. PMID: 16797988

4

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.

Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q, Moulick K, Aguirre J, Wu N, Greengard P, Chiosis G. Luo W, et al. Among authors: chiosis g. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. doi: 10.1073/pnas.0701055104. Epub 2007 May 21. Proc Natl Acad Sci U S A. 2007. PMID: 17517623 Free PMC article.

5

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.

Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Rodina A, et al. Among authors: chiosis g. Nat Chem Biol. 2007 Aug;3(8):498-507. doi: 10.1038/nchembio.2007.10. Epub 2007 Jul 1. Nat Chem Biol. 2007. PMID: 17603540

6

High-throughput screening fluorescence polarization assay for tumor-specific Hsp90.

Du Y, Moulick K, Rodina A, Aguirre J, Felts S, Dingledine R, Fu H, Chiosis G. Du Y, et al. Among authors: chiosis g. J Biomol Screen. 2007 Oct;12(7):915-24. doi: 10.1177/1087057107306067. J Biomol Screen. 2007. PMID: 17942784

7

Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?

Luo W, Rodina A, Chiosis G. Luo W, et al. Among authors: chiosis g. BMC Neurosci. 2008 Dec 3;9 Suppl 2(Suppl 2):S7. doi: 10.1186/1471-2202-9-S2-S7. BMC Neurosci. 2008. PMID: 19090995 Free PMC article. Review.

8

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G. Caldas-Lopes E, et al. Among authors: chiosis g. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106. Epub 2009 May 5. Proc Natl Acad Sci U S A. 2009. PMID: 19416831 Free PMC article.

9

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.

Taldone T, Gillan V, Sun W, Rodina A, Patel P, Maitland K, O'Neill K, Chiosis G, Devaney E. Taldone T, et al. Among authors: chiosis g. PLoS Negl Trop Dis. 2010 Jun 15;4(6):e714. doi: 10.1371/journal.pntd.0000714. PLoS Negl Trop Dis. 2010. PMID: 20559560 Free PMC article.

10

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.

Marubayashi S, Koppikar P, Taldone T, Abdel-Wahab O, West N, Bhagwat N, Caldas-Lopes E, Ross KN, Gönen M, Gozman A, Ahn JH, Rodina A, Ouerfelli O, Yang G, Hedvat C, Bradner JE, Chiosis G, Levine RL. Marubayashi S, et al. Among authors: chiosis g. J Clin Invest. 2010 Oct;120(10):3578-93. doi: 10.1172/JCI42442. Epub 2010 Sep 13. J Clin Invest. 2010. PMID: 20852385 Free PMC article.

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