Nikaido H - Search Results

1

Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway.

Su CC, Li M, Gu R, Takatsuka Y, McDermott G, Nikaido H, Yu EW. Su CC, et al. Among authors: nikaido h. J Bacteriol. 2006 Oct;188(20):7290-6. doi: 10.1128/JB.00684-06. J Bacteriol. 2006. PMID: 17015668 Free PMC article.

2

Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump.

Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr. Yu EW, et al. Among authors: nikaido h. Science. 2003 May 9;300(5621):976-80. doi: 10.1126/science.1083137. Science. 2003. PMID: 12738864

3

AcrB multidrug efflux pump of Escherichia coli: composite substrate-binding cavity of exceptional flexibility generates its extremely wide substrate specificity.

Yu EW, Aires JR, Nikaido H. Yu EW, et al. Among authors: nikaido h. J Bacteriol. 2003 Oct;185(19):5657-64. doi: 10.1128/JB.185.19.5657-5664.2003. J Bacteriol. 2003. PMID: 13129936 Free PMC article. Review. No abstract available.

4

A periplasmic drug-binding site of the AcrB multidrug efflux pump: a crystallographic and site-directed mutagenesis study.

Yu EW, Aires JR, McDermott G, Nikaido H. Yu EW, et al. Among authors: nikaido h. J Bacteriol. 2005 Oct;187(19):6804-15. doi: 10.1128/JB.187.19.6804-6815.2005. J Bacteriol. 2005. PMID: 16166543 Free PMC article.

5

Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network.

Takatsuka Y, Nikaido H. Takatsuka Y, et al. Among authors: nikaido h. J Bacteriol. 2006 Oct;188(20):7284-9. doi: 10.1128/JB.00683-06. J Bacteriol. 2006. PMID: 17015667 Free PMC article.

6

Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli.

Takatsuka Y, Nikaido H. Takatsuka Y, et al. Among authors: nikaido h. J Bacteriol. 2007 Dec;189(23):8677-84. doi: 10.1128/JB.01127-07. Epub 2007 Sep 28. J Bacteriol. 2007. PMID: 17905989 Free PMC article.

7

Ligand-transporter interaction in the AcrB multidrug efflux pump determined by fluorescence polarization assay.

Su CC, Yu EW. Su CC, et al. FEBS Lett. 2007 Oct 16;581(25):4972-6. doi: 10.1016/j.febslet.2007.09.035. Epub 2007 Sep 25. FEBS Lett. 2007. PMID: 17910961 Free PMC article.

8

Mechanisms of RND multidrug efflux pumps.

Nikaido H, Takatsuka Y. Nikaido H, et al. Biochim Biophys Acta. 2009 May;1794(5):769-81. doi: 10.1016/j.bbapap.2008.10.004. Epub 2008 Nov 3. Biochim Biophys Acta. 2009. PMID: 19026770 Free PMC article. Review.

9

Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism.

Takatsuka Y, Nikaido H. Takatsuka Y, et al. Among authors: nikaido h. J Bacteriol. 2009 Mar;191(6):1729-37. doi: 10.1128/JB.01441-08. Epub 2008 Dec 5. J Bacteriol. 2009. PMID: 19060146 Free PMC article.

10

Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli.

Takatsuka Y, Chen C, Nikaido H. Takatsuka Y, et al. Among authors: nikaido h. Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6559-65. doi: 10.1073/pnas.1001460107. Epub 2010 Mar 8. Proc Natl Acad Sci U S A. 2010. PMID: 20212112 Free PMC article.

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