Chan KK - Search Results

1

Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.

Fang L, Battisti RF, Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan KK, Martin EW Jr, Wang PG, Sun D. Fang L, et al. Among authors: chan kk. J Med Chem. 2006 Oct 19;49(21):6290-7. doi: 10.1021/jm060647f. J Med Chem. 2006. PMID: 17034135 Free PMC article.

2

Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance.

Fang L, Zhang G, Li C, Zheng X, Zhu L, Xiao JJ, Szakacs G, Nadas J, Chan KK, Wang PG, Sun D. Fang L, et al. Among authors: chan kk. J Med Chem. 2006 Feb 9;49(3):932-41. doi: 10.1021/jm050800q. J Med Chem. 2006. PMID: 16451059

3

Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients.

Fang L, Holford NH, Hinkle G, Cao X, Xiao JJ, Bloomston M, Gibbs S, Saif OH, Dalton JT, Chan KK, Schlom J, Martin EW Jr, Sun D. Fang L, et al. Among authors: chan kk. J Clin Pharmacol. 2007 Feb;47(2):227-37. doi: 10.1177/0091270006293758. J Clin Pharmacol. 2007. PMID: 17244774 Clinical Trial.

4

Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry.

Wei X, Dai G, Liu Z, Cheng H, Xie Z, Marcucci G, Chan KK. Wei X, et al. Among authors: chan kk. AAPS J. 2006;8(4):E743-55. doi: 10.1208/aapsj080484. AAPS J. 2006. PMID: 17285740 Free PMC article.

5

Enzyme kinetics of GTI-2040, a phosphorothioate oligonucleotide targeting ribonucleotide reductase.

Wei X, Dai G, Liu Z, Cheng H, Xie Z, Klisovic R, Marcucci G, Chan KK. Wei X, et al. Among authors: chan kk. Drug Metab Dispos. 2008 Nov;36(11):2227-33. doi: 10.1124/dmd.108.021295. Epub 2008 Jul 24. Drug Metab Dispos. 2008. PMID: 18653746 Clinical Trial.

6

Pharmacokinetics of voriconazole following intravenous and oral administration and body fluid concentrations of voriconazole following repeated oral administration in horses.

Colitz CM, Latimer FG, Cheng H, Chan KK, Reed SM, Pennick GJ. Colitz CM, et al. Among authors: chan kk. Am J Vet Res. 2007 Oct;68(10):1115-21. doi: 10.2460/ajvr.68.10.1115. Am J Vet Res. 2007. PMID: 17916020 Free article.

7

Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS.

Cheng H, Liu Z, Blum W, Byrd JC, Klisovic R, Grever MR, Marcucci G, Chan KK. Cheng H, et al. Among authors: chan kk. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May 1;850(1-2):206-12. doi: 10.1016/j.jchromb.2006.11.027. Epub 2006 Dec 4. J Chromatogr B Analyt Technol Biomed Life Sci. 2007. PMID: 17147984

8

Phase I and pharmacokinetic study of erlotinib (OSI-774) in combination with docetaxel in squamous cell carcinoma of the head and neck (SSCHN).

Kraut EH, Rhoades C, Zhang Y, Cheng H, Aimiumu J, Chen P, Lang J, Young DC, Agrawal A, Dancey J, Chan KK, Grever MR. Kraut EH, et al. Among authors: chan kk. Cancer Chemother Pharmacol. 2011 Mar;67(3):579-86. doi: 10.1007/s00280-010-1332-y. Epub 2010 May 19. Cancer Chemother Pharmacol. 2011. PMID: 20490801 Free PMC article. Clinical Trial.

9

Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents.

Cheng H, Xie Z, Jones WP, Wei XT, Liu Z, Wang D, Kulp SK, Wang J, Coss CC, Chen CS, Marcucci G, Garzon R, Covey JM, Phelps MA, Chan KK. Cheng H, et al. Among authors: chan kk. AAPS J. 2016 May;18(3):737-45. doi: 10.1208/s12248-016-9876-3. Epub 2016 Mar 4. AAPS J. 2016. PMID: 26943915 Free PMC article.

10

Curcumin is a potent DNA hypomethylation agent.

Liu Z, Xie Z, Jones W, Pavlovicz RE, Liu S, Yu J, Li PK, Lin J, Fuchs JR, Marcucci G, Li C, Chan KK. Liu Z, et al. Among authors: chan kk. Bioorg Med Chem Lett. 2009 Feb 1;19(3):706-9. doi: 10.1016/j.bmcl.2008.12.041. Epub 2008 Dec 14. Bioorg Med Chem Lett. 2009. PMID: 19112019

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