Reigan P - Search Results

1

Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.

Fang L, Battisti RF, Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan KK, Martin EW Jr, Wang PG, Sun D. Fang L, et al. Among authors: reigan p. J Med Chem. 2006 Oct 19;49(21):6290-7. doi: 10.1021/jm060647f. J Med Chem. 2006. PMID: 17034135 Free PMC article.

2

A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.

Reigan P, Siegel D, Guo W, Ross D. Reigan P, et al. Mol Pharmacol. 2011 May;79(5):823-32. doi: 10.1124/mol.110.070086. Epub 2011 Feb 1. Mol Pharmacol. 2011. PMID: 21285336 Free PMC article.

3

Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action.

Guo W, Reigan P, Siegel D, Ross D. Guo W, et al. Among authors: reigan p. Drug Metab Dispos. 2008 Oct;36(10):2050-7. doi: 10.1124/dmd.108.022004. Epub 2008 Jul 17. Drug Metab Dispos. 2008. PMID: 18635747 Free PMC article.

4

The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins.

Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. Guo W, et al. Among authors: reigan p. Mol Pharmacol. 2006 Oct;70(4):1194-203. doi: 10.1124/mol.106.025643. Epub 2006 Jul 6. Mol Pharmacol. 2006. PMID: 16825487

5

Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.

Colucci MA, Reigan P, Siegel D, Chilloux A, Ross D, Moody CJ. Colucci MA, et al. Among authors: reigan p. J Med Chem. 2007 Nov 15;50(23):5780-9. doi: 10.1021/jm070396q. Epub 2007 Oct 18. J Med Chem. 2007. PMID: 17944451 Free PMC article.

6

Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition.

Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. Guo W, et al. Among authors: reigan p. Cancer Res. 2005 Nov 1;65(21):10006-15. doi: 10.1158/0008-5472.CAN-05-2029. Cancer Res. 2005. PMID: 16267026

7

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.

Reigan P, Colucci MA, Siegel D, Chilloux A, Moody CJ, Ross D. Reigan P, et al. Biochemistry. 2007 May 22;46(20):5941-50. doi: 10.1021/bi700008y. Epub 2007 Apr 25. Biochemistry. 2007. PMID: 17455910

8

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems.

Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D. Yan C, et al. Among authors: reigan p. Biochemistry. 2011 Aug 9;50(31):6678-88. doi: 10.1021/bi2002967. Epub 2011 Jul 19. Biochemistry. 2011. PMID: 21718050 Free PMC article.

9

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.

Dehn DL, Siegel D, Zafar KS, Reigan P, Swann E, Moody CJ, Ross D. Dehn DL, et al. Among authors: reigan p. Mol Cancer Ther. 2006 Jul;5(7):1702-9. doi: 10.1158/1535-7163.MCT-06-0105. Mol Cancer Ther. 2006. PMID: 16891456

10

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

Reigan P, Edwards PN, Gbaj A, Cole C, Barry ST, Page KM, Ashton SE, Luke RW, Douglas KT, Stratford IJ, Jaffar M, Bryce RA, Freeman S. Reigan P, et al. J Med Chem. 2005 Jan 27;48(2):392-402. doi: 10.1021/jm049494r. J Med Chem. 2005. PMID: 15658853

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