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Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Stuyver LJ, McBrayer TR, Tharnish PM, Clark J, Hollecker L, Lostia S, Nachman T, Grier J, Bennett MA, Xie MY, Schinazi RF, Morrey JD, Julander JL, Furman PA, Otto MJ. Stuyver LJ, et al. Among authors: furman pa. Antivir Chem Chemother. 2006;17(2):79-87. doi: 10.1177/095632020601700203. Antivir Chem Chemother. 2006. PMID: 17042329 Free article.
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
Murakami E, Bao H, Ramesh M, McBrayer TR, Whitaker T, Micolochick Steuer HM, Schinazi RF, Stuyver LJ, Obikhod A, Otto MJ, Furman PA. Murakami E, et al. Among authors: furman pa. Antimicrob Agents Chemother. 2007 Feb;51(2):503-9. doi: 10.1128/AAC.00400-06. Epub 2006 Nov 13. Antimicrob Agents Chemother. 2007. PMID: 17101674 Free PMC article.
The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Murakami E, Niu C, Bao H, Micolochick Steuer HM, Whitaker T, Nachman T, Sofia MA, Wang P, Otto MJ, Furman PA. Murakami E, et al. Among authors: furman pa. Antimicrob Agents Chemother. 2008 Feb;52(2):458-64. doi: 10.1128/AAC.01184-07. Epub 2007 Nov 12. Antimicrob Agents Chemother. 2008. PMID: 17999967 Free PMC article.
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA. Lam AM, et al. Among authors: furman pa. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1. Antimicrob Agents Chemother. 2010. PMID: 20516278 Free PMC article.
Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.
Chang W, Du J, Rachakonda S, Ross BS, Convers-Reignier S, Yau WT, Pons JF, Murakami E, Bao H, Steuer HM, Furman PA, Otto MJ, Sofia MJ. Chang W, et al. Among authors: furman pa. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4539-43. doi: 10.1016/j.bmcl.2010.06.025. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20580554
Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.
Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, Chang W, Espiritu C, Bansal S, Lam AM, Otto MJ, Sofia MJ, Furman PA. Murakami E, et al. Among authors: furman pa. J Biol Chem. 2010 Nov 5;285(45):34337-47. doi: 10.1074/jbc.M110.161802. Epub 2010 Aug 26. J Biol Chem. 2010. PMID: 20801890 Free PMC article.
109 results