Zhang YQ - Search Results

1

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.

Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J. Auld DS, et al. Among authors: zhang yq. Methods Enzymol. 2006;414:566-89. doi: 10.1016/S0076-6879(06)14029-X. Methods Enzymol. 2006. PMID: 17110211

2

A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor.

Davis RE, Zhang YQ, Southall N, Staudt LM, Austin CP, Inglese J, Auld DS. Davis RE, et al. Among authors: zhang yq. Assay Drug Dev Technol. 2007 Feb;5(1):85-103. doi: 10.1089/adt.2006.048. Assay Drug Dev Technol. 2007. PMID: 17355202

3

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.

Xie Y, Deng S, Thomas CJ, Liu Y, Zhang YQ, Rinderspacher A, Huang W, Gong G, Wyler M, Cayanis E, Aulner N, Többen U, Chung C, Pampou S, Southall N, Vidović D, Schürer S, Branden L, Davis RE, Staudt LM, Inglese J, Austin CP, Landry DW, Smith DH, Auld DS. Xie Y, et al. Among authors: zhang yq. Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. doi: 10.1016/j.bmcl.2007.10.100. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 18024113 Free PMC article.

4

A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.

Auld DS, Zhang YQ, Southall NT, Rai G, Landsman M, MacLure J, Langevin D, Thomas CJ, Austin CP, Inglese J. Auld DS, et al. Among authors: zhang yq. J Med Chem. 2009 Mar 12;52(5):1450-8. doi: 10.1021/jm8014525. J Med Chem. 2009. PMID: 19215089 Free PMC article.

5

Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening.

Nilubol N, Zhang L, Shen M, Zhang YQ, He M, Austin CP, Kebebew E. Nilubol N, et al. Among authors: zhang l, zhang yq. J Transl Med. 2012 Sep 21;10:198. doi: 10.1186/1479-5876-10-198. J Transl Med. 2012. PMID: 22999104 Free PMC article.

6

Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs.

Shen M, Zhang Y, Saba N, Austin CP, Wiestner A, Auld DS. Shen M, et al. PLoS One. 2013 Sep 20;8(9):e75252. doi: 10.1371/journal.pone.0075252. eCollection 2013. PLoS One. 2013. PMID: 24073257 Free PMC article.

7

Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.

Hu Z, Hu X, He S, Yim HJ, Xiao J, Swaroop M, Tanega C, Zhang YQ, Yi G, Kao CC, Marugan J, Ferrer M, Zheng W, Southall N, Liang TJ. Hu Z, et al. Among authors: zhang yq. Antiviral Res. 2015 Dec;124:20-9. doi: 10.1016/j.antiviral.2015.10.018. Epub 2015 Oct 26. Antiviral Res. 2015. PMID: 26515788 Free PMC article.

8

A Class of Diacylglycerol Acyltransferase 1 Inhibitors Identified by a Combination of Phenotypic High-throughput Screening, Genomics, and Genetics.

Tschapalda K, Zhang YQ, Liu L, Golovnina K, Schlemper T, Eichmann TO, Lal-Nag M, Sreenivasan U, McLenithan J, Ziegler S, Sztalryd C, Lass A, Auld D, Oliver B, Waldmann H, Li Z, Shen M, Boxer MB, Beller M. Tschapalda K, et al. Among authors: zhang yq. EBioMedicine. 2016 Jun;8:49-59. doi: 10.1016/j.ebiom.2016.04.014. Epub 2016 Apr 16. EBioMedicine. 2016. PMID: 27428418 Free PMC article.

9

Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.

Shen M, Asawa R, Zhang YQ, Cunningham E, Sun H, Tropsha A, Janzen WP, Muratov EN, Capuzzi SJ, Farag S, Jadhav A, Blatt J, Simeonov A, Martinez NJ. Shen M, et al. Among authors: zhang yq. Oncotarget. 2017 Dec 19;9(4):4758-4772. doi: 10.18632/oncotarget.23462. eCollection 2018 Jan 12. Oncotarget. 2017. PMID: 29435139 Free PMC article.

10

Synergistic combination of flavopiridol and carfilzomib targets commonly dysregulated pathways in adrenocortical carcinoma and has biomarkers of response.

Nilubol N, Boufraqech M, Zhang L, Gaskins K, Shen M, Zhang YQ, Gara SK, Austin CP, Kebebew E. Nilubol N, et al. Among authors: zhang l, zhang yq. Oncotarget. 2018 Aug 31;9(68):33030-33042. doi: 10.18632/oncotarget.26050. eCollection 2018 Aug 31. Oncotarget. 2018. PMID: 30250647 Free PMC article.

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