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The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.
Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Vela JP, Martin SR, Reed J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoé G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI. Loffredo JT, et al. J Virol. 2007 Mar;81(6):2624-34. doi: 10.1128/JVI.01912-06. Epub 2006 Dec 27. J Virol. 2007. PMID: 17192314 Free PMC article.
Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication.
Friedrich TC, Valentine LE, Yant LJ, Rakasz EG, Piaskowski SM, Furlott JR, Weisgrau KL, Burwitz B, May GE, León EJ, Soma T, Napoe G, Capuano SV 3rd, Wilson NA, Watkins DI. Friedrich TC, et al. Among authors: burwitz b. J Virol. 2007 Apr;81(7):3465-76. doi: 10.1128/JVI.02392-06. Epub 2007 Jan 24. J Virol. 2007. PMID: 17251286 Free PMC article.
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.
Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz BJ, Stephany JJ, Loffredo JT, Allison DB, Adnan S, Hoji A, Wilson NA, Friedrich TC, Lifson JD, Yang OO, Watkins DI. Sacha JB, et al. Among authors: burwitz bj. J Immunol. 2007 Mar 1;178(5):2746-54. doi: 10.4049/jimmunol.178.5.2746. J Immunol. 2007. PMID: 17312117 Free PMC article.
CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.
Loffredo JT, Friedrich TC, León EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontkivska H, Hughes AL, Sette A, Watkins DI. Loffredo JT, et al. PLoS One. 2007 Nov 14;2(11):e1152. doi: 10.1371/journal.pone.0001152. PLoS One. 2007. PMID: 18000532 Free PMC article.
Mauritian cynomolgus macaques share two exceptionally common major histocompatibility complex class I alleles that restrict simian immunodeficiency virus-specific CD8+ T cells.
Burwitz BJ, Pendley CJ, Greene JM, Detmer AM, Lhost JJ, Karl JA, Piaskowski SM, Rudersdorf RA, Wallace LT, Bimber BN, Loffredo JT, Cox DG, Bardet W, Hildebrand W, Wiseman RW, O'Connor SL, O'Connor DH. Burwitz BJ, et al. J Virol. 2009 Jun;83(12):6011-9. doi: 10.1128/JVI.00199-09. Epub 2009 Apr 1. J Virol. 2009. PMID: 19339351 Free PMC article.
MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques.
O'Connor SL, Lhost JJ, Becker EA, Detmer AM, Johnson RC, Macnair CE, Wiseman RW, Karl JA, Greene JM, Burwitz BJ, Bimber BN, Lank SM, Tuscher JJ, Mee ET, Rose NJ, Desrosiers RC, Hughes AL, Friedrich TC, Carrington M, O'Connor DH. O'Connor SL, et al. Sci Transl Med. 2010 Mar 10;2(22):22ra18. doi: 10.1126/scitranslmed.3000524. Sci Transl Med. 2010. PMID: 20375000 Free PMC article.
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