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Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Barbour LA, et al. J Biol Chem. 2005 Nov 11;280(45):37489-94. doi: 10.1074/jbc.M506967200. Epub 2005 Sep 8. J Biol Chem. 2005. PMID: 16166093 Free article.
Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study.
Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Hernandez TL, et al. Among authors: barbour la. Diabetes Care. 2016 Jan;39(1):39-42. doi: 10.2337/dc15-0515. Epub 2015 Jul 29. Diabetes Care. 2016. PMID: 26223240 Free PMC article. Clinical Trial.
289 results