Truchon JF - Search Results

1

A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds.

Oballa RM, Truchon JF, Bayly CI, Chauret N, Day S, Crane S, Berthelette C. Oballa RM, et al. Among authors: truchon jf. Bioorg Med Chem Lett. 2007 Feb 15;17(4):998-1002. doi: 10.1016/j.bmcl.2006.11.044. Epub 2006 Nov 17. Bioorg Med Chem Lett. 2007. PMID: 17157022

2

Beta-substituted cyclohexanecarboxamide cathepsin K inhibitors: modification of the 1,2-disubstituted aromatic core.

Robichaud J, Bayly CI, Black WC, Desmarais S, Léger S, Massé F, McKay DJ, Oballa RM, Pâquet J, Percival MD, Truchon JF, Wesolowski G, Crane SN. Robichaud J, et al. Among authors: truchon jf. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3146-51. doi: 10.1016/j.bmcl.2007.03.028. Epub 2007 Mar 15. Bioorg Med Chem Lett. 2007. PMID: 17408953

3

Primary amides as selective inhibitors of cathepsin K.

Léger S, Bayly CI, Black WC, Desmarais S, Falgueyret JP, Massé F, Percival MD, Truchon JF. Léger S, et al. Among authors: truchon jf. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4328-32. doi: 10.1016/j.bmcl.2007.05.024. Epub 2007 May 16. Bioorg Med Chem Lett. 2007. PMID: 17544269

4

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.

Guay D, Beaulieu C, Truchon JF, Jagadeeswar Reddy T, Zamboni R, Bayly CI, Methot N, Rubin J, Ethier D, David Percival M. Guay D, et al. Among authors: truchon jf. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5392-6. doi: 10.1016/j.bmcl.2009.07.114. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19665376

5

In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites.

Nicoll-Griffith DA, Seto C, Aubin Y, Lévesque JF, Chauret N, Day S, Silva JM, Trimble LA, Truchon JF, Berthelette C, Lachance N, Wang Z, Sturino C, Braun M, Zamboni R, Young RN. Nicoll-Griffith DA, et al. Among authors: truchon jf. Bioorg Med Chem Lett. 2007 Jan 15;17(2):301-4. doi: 10.1016/j.bmcl.2006.10.055. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17095220

6

GLARE: a new approach for filtering large reagent lists in combinatorial library design using product properties.

Truchon JF, Bayly CI. Truchon JF, et al. J Chem Inf Model. 2006 Jul-Aug;46(4):1536-48. doi: 10.1021/ci0504871. J Chem Inf Model. 2006. PMID: 16859286

7

Evaluating virtual screening methods: good and bad metrics for the "early recognition" problem.

Truchon JF, Bayly CI. Truchon JF, et al. J Chem Inf Model. 2007 Mar-Apr;47(2):488-508. doi: 10.1021/ci600426e. Epub 2007 Feb 9. J Chem Inf Model. 2007. PMID: 17288412

8

Accurate Molecular Polarizabilities Based on Continuum Electrostatics.

Truchon JF, Nicholls A, Iftimie RI, Roux B, Bayly CI. Truchon JF, et al. J Chem Theory Comput. 2008 Sep 9;4(9):1480-1493. doi: 10.1021/ct800123c. J Chem Theory Comput. 2008. PMID: 23646034 Free PMC article.

9

Integrated Continuum Dielectric Approaches to treat Molecular Polarizability and the Condensed Phase: Refractive Index and Implicit Solvation.

Truchon JF, Nicholls A, Roux B, Iftimie RI, Bayly CI. Truchon JF, et al. J Chem Theory Comput. 2009 Jul 14;5(7):1785-1802. doi: 10.1021/ct900029d. J Chem Theory Comput. 2009. PMID: 24826083 Free PMC article. No abstract available.

10

The identification of potent, selective, and bioavailable cathepsin S inhibitors.

Gauthier JY, Black WC, Courchesne I, Cromlish W, Desmarais S, Houle R, Lamontagne S, Li CS, Massé F, McKay DJ, Ouellet M, Robichaud J, Truchon JF, Truong VL, Wang Q, Percival MD. Gauthier JY, et al. Among authors: truchon jf. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4929-33. doi: 10.1016/j.bmcl.2007.06.023. Epub 2007 Jun 10. Bioorg Med Chem Lett. 2007. PMID: 17590332

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