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Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis.
Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK. Miller TM, et al. Among authors: kaspar bk. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19546-51. doi: 10.1073/pnas.0609411103. Epub 2006 Dec 12. Proc Natl Acad Sci U S A. 2006. PMID: 17164329 Free PMC article.
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS.
Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, Cleveland DW. Sun S, et al. Among authors: kaspar bk. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6993-7002. doi: 10.1073/pnas.1520639112. Epub 2015 Nov 30. Proc Natl Acad Sci U S A. 2015. PMID: 26621731 Free PMC article.
Adeno-associated virus effectively mediates conditional gene modification in the brain.
Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage FH. Kaspar BK, et al. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2320-5. doi: 10.1073/pnas.042678699. Epub 2002 Feb 12. Proc Natl Acad Sci U S A. 2002. PMID: 11842206 Free PMC article.
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.
Meyer K, Ferraiuolo L, Miranda CJ, Likhite S, McElroy S, Renusch S, Ditsworth D, Lagier-Tourenne C, Smith RA, Ravits J, Burghes AH, Shaw PJ, Cleveland DW, Kolb SJ, Kaspar BK. Meyer K, et al. Among authors: kaspar bk. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):829-32. doi: 10.1073/pnas.1314085111. Epub 2013 Dec 30. Proc Natl Acad Sci U S A. 2014. PMID: 24379375 Free PMC article.
Ex vivo and in vivo gene delivery to the brain.
Suhonen J, Ray J, Blömer U, Gage FH, Kaspar B. Suhonen J, et al. Curr Protoc Hum Genet. 2006 Nov;Chapter 13:Unit 13.3. doi: 10.1002/0471142905.hg1303s51. Curr Protoc Hum Genet. 2006. PMID: 18428389 Review.
116 results