Holcomb VB - Search Results

1

Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.

van de Ven M, Andressoo JO, Holcomb VB, von Lindern M, Jong WM, De Zeeuw CI, Suh Y, Hasty P, Hoeijmakers JH, van der Horst GT, Mitchell JR. van de Ven M, et al. Among authors: holcomb vb. PLoS Genet. 2006 Dec 15;2(12):e192. doi: 10.1371/journal.pgen.0020192. Epub 2006 Oct 2. PLoS Genet. 2006. PMID: 17173483 Free PMC article.

2

Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.

van de Ven M, Andressoo JO, Holcomb VB, Hasty P, Suh Y, van Steeg H, Garinis GA, Hoeijmakers JH, Mitchell JR. van de Ven M, et al. Among authors: holcomb vb. Mech Ageing Dev. 2007 Jan;128(1):58-63. doi: 10.1016/j.mad.2006.11.011. Epub 2006 Nov 28. Mech Ageing Dev. 2007. PMID: 17126380 Free PMC article. Review.

3

Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs.

Holcomb VB, Vogel H, Hasty P. Holcomb VB, et al. Mech Ageing Dev. 2007 Nov-Dec;128(11-12):601-8. doi: 10.1016/j.mad.2007.08.006. Epub 2007 Sep 12. Mech Ageing Dev. 2007. PMID: 17928034 Free PMC article.

4

Unlike p53, p27 failed to exhibit an anti-tumor genetic interaction with Ku80.

Holcomb VB, Vogel H, Hasty P. Holcomb VB, et al. Cell Cycle. 2009 Aug;8(15):2463-6. doi: 10.4161/cc.8.15.9249. Epub 2009 Aug 11. Cell Cycle. 2009. PMID: 19597334

5

Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer.

Li H, Vogel H, Holcomb VB, Gu Y, Hasty P. Li H, et al. Among authors: holcomb vb. Mol Cell Biol. 2007 Dec;27(23):8205-14. doi: 10.1128/MCB.00785-07. Epub 2007 Sep 17. Mol Cell Biol. 2007. PMID: 17875923 Free PMC article.

6

Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs.

Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P. Holcomb VB, et al. Oncogene. 2006 Nov 16;25(54):7159-65. doi: 10.1038/sj.onc.1209704. Epub 2006 Jun 5. Oncogene. 2006. PMID: 16751807

7

Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.

Holcomb VB, Rodier F, Choi Y, Busuttil RA, Vogel H, Vijg J, Campisi J, Hasty P. Holcomb VB, et al. Cancer Res. 2008 Nov 15;68(22):9497-502. doi: 10.1158/0008-5472.CAN-08-2085. Cancer Res. 2008. PMID: 19010925 Free PMC article.

8

HPRT minigene generates chimeric transcripts as a by-product of gene targeting.

Holcomb VB, Kim TM, Dumitrache LC, Ma SM, Chen MJ, Hasty P. Holcomb VB, et al. Genesis. 2007 May;45(5):275-81. doi: 10.1002/dvg.20300. Genesis. 2007. PMID: 17457929

9

Alcohol consumption promotes mammary tumor growth and insulin sensitivity.

Hong J, Holcomb VB, Tekle SA, Fan B, Núñez NP. Hong J, et al. Among authors: holcomb vb. Cancer Lett. 2010 Aug 28;294(2):229-35. doi: 10.1016/j.canlet.2010.02.004. Epub 2010 Mar 3. Cancer Lett. 2010. PMID: 20202743 Free PMC article.

10

Alcohol promotes mammary tumor development via the estrogen pathway in estrogen receptor alpha-negative HER2/neu mice.

Wong AW, Dunlap SM, Holcomb VB, Nunez NP. Wong AW, et al. Among authors: holcomb vb. Alcohol Clin Exp Res. 2012 Apr;36(4):577-87. doi: 10.1111/j.1530-0277.2011.01654.x. Epub 2011 Oct 7. Alcohol Clin Exp Res. 2012. PMID: 21981381

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