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Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen.
Maddry JA, Chen X, Jonsson CB, Ananthan S, Hobrath J, Smee DF, Noah JW, Noah D, Xu X, Jia F, Maddox C, Sosa MI, White EL, Severson WE. Maddry JA, et al. Among authors: white el. J Biomol Screen. 2011 Jan;16(1):73-81. doi: 10.1177/1087057110384613. Epub 2010 Nov 8. J Biomol Screen. 2011. PMID: 21059874 Free PMC article.
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase.
White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Manouvakhova A, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM 3rd. White EL, et al. J Biomol Screen. 2007 Feb;12(1):100-5. doi: 10.1177/1087057106296484. Epub 2006 Dec 14. J Biomol Screen. 2007. PMID: 17175524
High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.
Ananthan S, Faaleolea ER, Goldman RC, Hobrath JV, Kwong CD, Laughon BE, Maddry JA, Mehta A, Rasmussen L, Reynolds RC, Secrist JA 3rd, Shindo N, Showe DN, Sosa MI, Suling WJ, White EL. Ananthan S, et al. Among authors: white el. Tuberculosis (Edinb). 2009 Sep;89(5):334-53. doi: 10.1016/j.tube.2009.05.008. Epub 2009 Sep 15. Tuberculosis (Edinb). 2009. PMID: 19758845 Free PMC article.
A high-throughput screening strategy to overcome virus instability.
Rasmussen L, Maddox C, Moore BP, Severson W, White EL. Rasmussen L, et al. Among authors: white el. Assay Drug Dev Technol. 2011 Apr;9(2):184-90. doi: 10.1089/adt.2010.0298. Epub 2010 Nov 4. Assay Drug Dev Technol. 2011. PMID: 21050067 Free PMC article.
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection.
Moore BP, Chung DH, Matharu DS, Golden JE, Maddox C, Rasmussen L, Noah JW, Sosa MI, Ananthan S, Tower NA, White EL, Jia F, Prisinzano TE, Aubé J, Jonsson CB, Severson WE. Moore BP, et al. Among authors: white el. J Med Chem. 2012 Oct 25;55(20):8582-7. doi: 10.1021/jm300612z. Epub 2012 Oct 16. J Med Chem. 2012. PMID: 23043370 Free PMC article.
209 results