Sorensen EJ - Search Results

1

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. Buey RM, et al. Among authors: sorensen ej. Nat Chem Biol. 2007 Feb;3(2):117-25. doi: 10.1038/nchembio853. Epub 2007 Jan 7. Nat Chem Biol. 2007. PMID: 17206139 Free article.

2

Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.

Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Edler MC, et al. Among authors: sorensen ej. Biochemistry. 2005 Aug 30;44(34):11525-38. doi: 10.1021/bi050660m. Biochemistry. 2005. PMID: 16114889

3

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer FA, Mühlethaler T, Estévez-Gallego J, Calvo E, Giménez-Abián JF, Risinger AL, Sorensen EJ, Vanderwal CD, Altmann KH, Mooberry SL, Steinmetz MO, Oliva MÁ, Prota AE, Díaz JF. Balaguer FA, et al. Among authors: sorensen ej. Int J Mol Sci. 2019 Mar 20;20(6):1392. doi: 10.3390/ijms20061392. Int J Mol Sci. 2019. PMID: 30897704 Free PMC article.

4

A synthesis of (+)-FR182877, featuring tandem transannular Diels-Alder reactions inspired by a postulated biogenesis.

Vosburg DA, Vanderwal CD, Sorensen EJ. Vosburg DA, et al. Among authors: sorensen ej. J Am Chem Soc. 2002 May 1;124(17):4552-3. doi: 10.1021/ja025885o. J Am Chem Soc. 2002. PMID: 11971689

5

An enantioselective synthesis of FR182877 provides a chemical rationalization of its structure and affords multigram quantities of its direct precursor.

Vanderwal CD, Vosburg DA, Weiler S, Sorensen EJ. Vanderwal CD, et al. Among authors: sorensen ej. J Am Chem Soc. 2003 May 7;125(18):5393-407. doi: 10.1021/ja021472b. J Am Chem Soc. 2003. PMID: 12720453

6

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. Hamel E, et al. Among authors: sorensen ej. Mol Pharmacol. 2006 Nov;70(5):1555-64. doi: 10.1124/mol.106.027847. Epub 2006 Aug 3. Mol Pharmacol. 2006. PMID: 16887932

7

(-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1.

Adam GC, Vanderwal CD, Sorensen EJ, Cravatt BF. Adam GC, et al. Among authors: sorensen ej. Angew Chem Int Ed Engl. 2003 Nov 17;42(44):5480-4. doi: 10.1002/anie.200352576. Angew Chem Int Ed Engl. 2003. PMID: 14618582 No abstract available.

8

Intramolecular allenolate acylations in studies toward a synthesis of FR182877.

Vanderwal CD, Vosburg DA, Sorensen EJ. Vanderwal CD, et al. Among authors: sorensen ej. Org Lett. 2001 Dec 27;3(26):4307-10. doi: 10.1021/ol016994v. Org Lett. 2001. PMID: 11784204

9

Postulated biogenesis of WS9885B and progress toward an enantioselective synthesis.

Vanderwal CD, Vosburg DA, Weiler S, Sorensen EJ. Vanderwal CD, et al. Among authors: sorensen ej. Org Lett. 1999 Aug 26;1(4):645-8. doi: 10.1021/ol990723r. Org Lett. 1999. PMID: 10823194

10

Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470.

Vosburg DA, Weiler S, Sorensen EJ. Vosburg DA, et al. Among authors: sorensen ej. Chirality. 2003 Feb;15(2):156-66. doi: 10.1002/chir.10181. Chirality. 2003. PMID: 12520508

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