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The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
Solinas M, Tanda G, Justinova Z, Wertheim CE, Yasar S, Piomelli D, Vadivel SK, Makriyannis A, Goldberg SR. Solinas M, et al. Among authors: justinova z. J Pharmacol Exp Ther. 2007 Apr;321(1):370-80. doi: 10.1124/jpet.106.114124. Epub 2007 Jan 8. J Pharmacol Exp Ther. 2007. PMID: 17210800
Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats.
Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinová Z, Mikics E, Haller J, Medalie J, Stroik J, Barnes C, Yasar S, Tanda G, Piomelli D, Fratta W, Goldberg SR. Scherma M, et al. Among authors: justinova z. J Pharmacol Exp Ther. 2008 Nov;327(2):482-90. doi: 10.1124/jpet.108.142224. Epub 2008 Aug 25. J Pharmacol Exp Ther. 2008. PMID: 18725543 Free PMC article.
The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
Scherma M, Justinová Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W, Makriyannis A, Vadivel SK, Gamaleddin I, Le Foll B, Goldberg SR. Scherma M, et al. Among authors: justinova z. Br J Pharmacol. 2012 Apr;165(8):2539-48. doi: 10.1111/j.1476-5381.2011.01467.x. Br J Pharmacol. 2012. PMID: 21557729 Free PMC article.
65 results