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The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
Solinas M, Tanda G, Justinova Z, Wertheim CE, Yasar S, Piomelli D, Vadivel SK, Makriyannis A, Goldberg SR. Solinas M, et al. Among authors: vadivel sk. J Pharmacol Exp Ther. 2007 Apr;321(1):370-80. doi: 10.1124/jpet.106.114124. Epub 2007 Jan 8. J Pharmacol Exp Ther. 2007. PMID: 17210800
The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition.
Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, Mikics E, Haller J, Yasar S, Tanda G, Goldberg SR. Scherma M, et al. Among authors: vadivel sk. Neuropharmacology. 2008 Jan;54(1):129-40. doi: 10.1016/j.neuropharm.2007.08.011. Epub 2007 Aug 19. Neuropharmacology. 2008. PMID: 17904589 Free PMC article.
The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
Scherma M, Justinová Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W, Makriyannis A, Vadivel SK, Gamaleddin I, Le Foll B, Goldberg SR. Scherma M, et al. Among authors: vadivel sk. Br J Pharmacol. 2012 Apr;165(8):2539-48. doi: 10.1111/j.1476-5381.2011.01467.x. Br J Pharmacol. 2012. PMID: 21557729 Free PMC article.
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Schindler CW, Scherma M, Redhi GH, Vadivel SK, Makriyannis A, Goldberg SR, Justinova Z. Schindler CW, et al. Among authors: vadivel sk. Psychopharmacology (Berl). 2016 May;233(10):1867-77. doi: 10.1007/s00213-016-4211-3. Epub 2016 Jan 23. Psychopharmacology (Berl). 2016. PMID: 26803499 Free PMC article.
Development of novel tail-modified anandamide analogs.
Yao F, Li C, Vadivel SK, Bowman AL, Makriyannis A. Yao F, et al. Among authors: vadivel sk. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5912-5. doi: 10.1016/j.bmcl.2008.07.110. Epub 2008 Jul 31. Bioorg Med Chem Lett. 2008. PMID: 18723350 Free PMC article.
27 results