Isse T - Search Results

1

Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.

Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K, Steinhoff L, Brandt M, Kleschyov AL, Schulz E, Lange K, Weiner H, Lehmann J, Lackner KJ, Kawamoto T, Münzel T, Daiber A. Wenzel P, et al. Among authors: isse t. Br J Pharmacol. 2007 Feb;150(4):526-33. doi: 10.1038/sj.bjp.0707116. Epub 2007 Jan 15. Br J Pharmacol. 2007. PMID: 17220910 Free PMC article.

2

Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism.

Oyama T, Isse T, Kagawa N, Kinaga T, Kim YD, Morita M, Sugio K, Weiner H, Yasumoto K, Kawamoto T. Oyama T, et al. Among authors: isse t. Front Biosci. 2005 Jan 1;10:951-60. doi: 10.2741/1589. Print 2005 Jan 1. Front Biosci. 2005. PMID: 15569633

3

Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study.

Kim YD, Oyama T, Isse T, Kim H, Kawamoto T. Kim YD, et al. Among authors: isse t. Arch Toxicol. 2005 Apr;79(4):192-5. doi: 10.1007/s00204-004-0630-8. Epub 2005 Jan 15. Arch Toxicol. 2005. PMID: 15654606

4

Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages.

Isse T, Matsuno K, Oyama T, Kitagawa K, Kawamoto T. Isse T, et al. Alcohol Clin Exp Res. 2005 Nov;29(11):1959-64. doi: 10.1097/01.alc.0000187161.07820.21. Alcohol Clin Exp Res. 2005. PMID: 16340452

5

Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality.

Isse T, Oyama T, Matsuno K, Uchiyama I, Kawamoto T. Isse T, et al. J Toxicol Sci. 2005 Dec;30(4):315-28. doi: 10.2131/jts.30.315. J Toxicol Sci. 2005. PMID: 16404140 Free article.

6

A pilot study on subacute ethanol treatment of ALDH2 KO mice.

Oyama T, Kim YD, Isse T, Phuong PT, Ogawa M, Yamaguchi T, Kinaga T, Yashima Y, Kim H, Kawamoto T. Oyama T, et al. Among authors: isse t. J Toxicol Sci. 2007 Oct;32(4):421-8. doi: 10.2131/jts.32.421. J Toxicol Sci. 2007. PMID: 17965556 Free article.

7

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity.

Isse T, Oyama T, Kitagawa K, Matsuno K, Matsumoto A, Yoshida A, Nakayama K, Nakayama K, Kawamoto T. Isse T, et al. Pharmacogenetics. 2002 Nov;12(8):621-6. doi: 10.1097/00008571-200211000-00006. Pharmacogenetics. 2002. PMID: 12439222

8

Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice.

Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T. Oyama T, et al. Among authors: isse t. Front Biosci. 2007 Jan 1;12:1927-34. doi: 10.2741/2198. Front Biosci. 2007. PMID: 17127431

9

A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype.

Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y, Endo Y, Kawamoto T. Ogawa M, et al. Among authors: isse t. Toxicol Lett. 2007 Jan 30;168(2):148-54. doi: 10.1016/j.toxlet.2006.11.010. Epub 2006 Nov 23. Toxicol Lett. 2007. PMID: 17166675

10

Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice.

Isse T, Oyama T, Matsuno K, Ogawa M, Narai-Suzuki R, Yamaguchi T, Murakami T, Kinaga T, Uchiyama I, Kawamoto T. Isse T, et al. J Toxicol Sci. 2005 Dec;30(4):329-37. doi: 10.2131/jts.30.329. J Toxicol Sci. 2005. PMID: 16404141 Free article.

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