Ort S - Search Results

1

Elucidation of the active conformation of the APS-kinase domain of human PAPS synthetase 1.

Sekulic N, Dietrich K, Paarmann I, Ort S, Konrad M, Lavie A. Sekulic N, et al. Among authors: ort s. J Mol Biol. 2007 Mar 23;367(2):488-500. doi: 10.1016/j.jmb.2007.01.025. Epub 2007 Jan 12. J Mol Biol. 2007. PMID: 17276460 Free PMC article.

2

Substrate-induced conformational changes in human UMP/CMP kinase.

Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A. Segura-Peña D, et al. Among authors: ort s. J Biol Chem. 2004 Aug 6;279(32):33882-9. doi: 10.1074/jbc.M401989200. Epub 2004 May 26. J Biol Chem. 2004. PMID: 15163660 Free article.

3

Structural basis for substrate promiscuity of dCK.

Sabini E, Hazra S, Ort S, Konrad M, Lavie A. Sabini E, et al. Among authors: ort s. J Mol Biol. 2008 May 2;378(3):607-21. doi: 10.1016/j.jmb.2008.02.061. Epub 2008 Mar 3. J Mol Biol. 2008. PMID: 18377927 Free PMC article.

4

Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.

Hazra S, Szewczak A, Ort S, Konrad M, Lavie A. Hazra S, et al. Among authors: ort s. Biochemistry. 2011 Apr 12;50(14):2870-80. doi: 10.1021/bi2001032. Epub 2011 Mar 16. Biochemistry. 2011. PMID: 21351740 Free PMC article.

5

Structure of human dCK suggests strategies to improve anticancer and antiviral therapy.

Sabini E, Ort S, Monnerjahn C, Konrad M, Lavie A. Sabini E, et al. Among authors: ort s. Nat Struct Biol. 2003 Jul;10(7):513-9. doi: 10.1038/nsb942. Nat Struct Biol. 2003. PMID: 12808445

6

Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.

Godsey MH, Ort S, Sabini E, Konrad M, Lavie A. Godsey MH, et al. Among authors: ort s. Biochemistry. 2006 Jan 17;45(2):452-61. doi: 10.1021/bi0518646. Biochemistry. 2006. PMID: 16401075

7

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase.

Hazra S, Sabini E, Ort S, Konrad M, Lavie A. Hazra S, et al. Among authors: ort s. Biochemistry. 2009 Feb 17;48(6):1256-63. doi: 10.1021/bi802062w. Biochemistry. 2009. PMID: 19159229 Free PMC article.

8

Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues.

Hazra S, Ort S, Konrad M, Lavie A. Hazra S, et al. Among authors: ort s. Biochemistry. 2010 Aug 10;49(31):6784-90. doi: 10.1021/bi100839e. Biochemistry. 2010. PMID: 20614893 Free PMC article.

9

Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues.

McSorley T, Ort S, Hazra S, Lavie A, Konrad M. McSorley T, et al. Among authors: ort s. FEBS Lett. 2008 Mar 5;582(5):720-4. doi: 10.1016/j.febslet.2008.01.048. Epub 2008 Feb 5. FEBS Lett. 2008. PMID: 18258203 Free PMC article.

10

A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing.

McSorley T, Ort S, Monnerjahn C, Konrad M. McSorley T, et al. Among authors: ort s. Biochem Pharmacol. 2014 Feb 1;87(3):435-44. doi: 10.1016/j.bcp.2013.11.011. Epub 2013 Dec 4. Biochem Pharmacol. 2014. PMID: 24316433

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