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Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis.
Dell'Aica I, Niero R, Piazza F, Cabrelle A, Sartor L, Colalto C, Brunetta E, Lorusso G, Benelli R, Albini A, Calabrese F, Agostini C, Garbisa S. Dell'Aica I, et al. Among authors: garbisa s. J Pharmacol Exp Ther. 2007 May;321(2):492-500. doi: 10.1124/jpet.106.116459. Epub 2007 Feb 8. J Pharmacol Exp Ther. 2007. PMID: 17289834 Free article.
Hyperforin inhibits cancer invasion and metastasis.
Donà M, Dell'Aica I, Pezzato E, Sartor L, Calabrese F, Della Barbera M, Donella-Deana A, Appendino G, Borsarini A, Caniato R, Garbisa S. Donà M, et al. Among authors: garbisa s. Cancer Res. 2004 Sep 1;64(17):6225-32. doi: 10.1158/0008-5472.CAN-04-0280. Cancer Res. 2004. PMID: 15342408
Inhibition of leukocyte elastase, polymorphonuclear chemoinvasion, and inflammation-triggered pulmonary fibrosis by a 4-alkyliden-beta-lactam with a galloyl moiety.
Dell'Aica I, Sartor L, Galletti P, Giacomini D, Quintavalla A, Calabrese F, Giacometti C, Brunetta E, Piazza F, Agostini C, Garbisa S. Dell'Aica I, et al. Among authors: garbisa s. J Pharmacol Exp Ther. 2006 Feb;316(2):539-46. doi: 10.1124/jpet.105.096248. Epub 2005 Oct 25. J Pharmacol Exp Ther. 2006. PMID: 16249367
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Gurrieri C, Piazza F, Gnoato M, Montini B, Biasutto L, Gattazzo C, Brunetta E, Cabrelle A, Cinetto F, Niero R, Facco M, Garbisa S, Calabrese F, Semenzato G, Agostini C. Gurrieri C, et al. Among authors: garbisa s. J Pharmacol Exp Ther. 2010 Mar;332(3):785-94. doi: 10.1124/jpet.109.153049. Epub 2009 Dec 3. J Pharmacol Exp Ther. 2010. PMID: 19959748
134 results