Hui R - Search Results

1

A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.

Bello AM, Poduch E, Fujihashi M, Amani M, Li Y, Crandall I, Hui R, Lee PI, Kain KC, Pai EF, Kotra LP. Bello AM, et al. Among authors: hui r. J Med Chem. 2007 Mar 8;50(5):915-21. doi: 10.1021/jm060827p. Epub 2007 Feb 10. J Med Chem. 2007. PMID: 17290979

2

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R. Vedadi M, et al. Among authors: hui r. Mol Biochem Parasitol. 2007 Jan;151(1):100-10. doi: 10.1016/j.molbiopara.2006.10.011. Epub 2006 Nov 13. Mol Biochem Parasitol. 2007. PMID: 17125854

3

Structures of parasitic CDPK domains point to a common mechanism of activation.

Wernimont AK, Amani M, Qiu W, Pizarro JC, Artz JD, Lin YH, Lew J, Hutchinson A, Hui R. Wernimont AK, et al. Among authors: hui r. Proteins. 2011 Mar;79(3):803-20. doi: 10.1002/prot.22919. Epub 2010 Dec 3. Proteins. 2011. PMID: 21287613

4

Characterization of a new phosphatase from Plasmodium.

Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC. Hills T, et al. Among authors: hui r. Mol Biochem Parasitol. 2011 Oct;179(2):69-79. doi: 10.1016/j.molbiopara.2011.06.001. Epub 2011 Jun 13. Mol Biochem Parasitol. 2011. PMID: 21689687

5

Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.

Osman KT, Ye J, Shi Z, Toker C, Lovato D, Jumani RS, Zuercher W, Huston CD, Edwards AM, Lautens M, Santhakumar V, Hui R. Osman KT, et al. Among authors: hui r. Bioorg Med Chem. 2017 Mar 1;25(5):1672-1680. doi: 10.1016/j.bmc.2017.01.036. Epub 2017 Jan 24. Bioorg Med Chem. 2017. PMID: 28162900

6

Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.

Rutaganira FU, Barks J, Dhason MS, Wang Q, Lopez MS, Long S, Radke JB, Jones NG, Maddirala AR, Janetka JW, El Bakkouri M, Hui R, Shokat KM, Sibley LD. Rutaganira FU, et al. Among authors: hui r. J Med Chem. 2017 Dec 28;60(24):9976-9989. doi: 10.1021/acs.jmedchem.7b01192. Epub 2017 Oct 9. J Med Chem. 2017. PMID: 28933846 Free PMC article.

7

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

Artz JD, Dunford JE, Arrowood MJ, Dong A, Chruszcz M, Kavanagh KL, Minor W, Russell RG, Ebetino FH, Oppermann U, Hui R. Artz JD, et al. Among authors: hui r. Chem Biol. 2008 Dec 22;15(12):1296-306. doi: 10.1016/j.chembiol.2008.10.017. Chem Biol. 2008. PMID: 19101474

8

Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.

El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA. El Bakkouri M, et al. Among authors: hui r. J Biol Chem. 2013 Jan 11;288(2):1022-31. doi: 10.1074/jbc.M112.416560. Epub 2012 Nov 28. J Biol Chem. 2013. PMID: 23192353 Free PMC article.

9

Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.

Dufe VT, Qiu W, Müller IB, Hui R, Walter RD, Al-Karadaghi S. Dufe VT, et al. Among authors: hui r. J Mol Biol. 2007 Oct 12;373(1):167-77. doi: 10.1016/j.jmb.2007.07.053. Epub 2007 Aug 2. J Mol Biol. 2007. PMID: 17822713

10

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.

Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R. Artz JD, et al. Among authors: hui r. J Biol Chem. 2011 Feb 4;286(5):3315-22. doi: 10.1074/jbc.M109.027235. Epub 2010 Nov 17. J Biol Chem. 2011. PMID: 21084289 Free PMC article.

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