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N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
Gu YG, Weitzberg M, Clark RF, Xu X, Li Q, Lubbers NL, Yang Y, Beno DW, Widomski DL, Zhang T, Hansen TM, Keyes RF, Waring JF, Carroll SL, Wang X, Wang R, Healan-Greenberg CH, Blomme EA, Beutel BA, Sham HL, Camp HS. Gu YG, et al. Among authors: xu x. J Med Chem. 2007 Mar 8;50(5):1078-82. doi: 10.1021/jm070035a. Epub 2007 Feb 14. J Med Chem. 2007. PMID: 17298049
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
Gu YG, Weitzberg M, Clark RF, Xu X, Li Q, Zhang T, Hansen TM, Liu G, Xin Z, Wang X, Wang R, McNally T, Zinker BA, Frevert EU, Camp HS, Beutel BA, Sham HL. Gu YG, et al. Among authors: xu x. J Med Chem. 2006 Jun 29;49(13):3770-3. doi: 10.1021/jm060484v. J Med Chem. 2006. PMID: 16789734
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A, Warder SE, Gu YG, Zinker BA, Blomme EA, Camp HS. Waring JF, et al. Among authors: xu x. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. doi: 10.1124/jpet.107.126938. Epub 2007 Nov 19. J Pharmacol Exp Ther. 2008. PMID: 18025247
Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.
Graneto MJ, Kurumbail RG, Vazquez ML, Shieh HS, Pawlitz JL, Williams JM, Stallings WC, Geng L, Naraian AS, Koszyk FJ, Stealey MA, Xu XD, Weier RM, Hanson GJ, Mourey RJ, Compton RP, Mnich SJ, Anderson GD, Monahan JB, Devraj R. Graneto MJ, et al. J Med Chem. 2007 Nov 15;50(23):5712-9. doi: 10.1021/jm0611915. Epub 2007 Oct 19. J Med Chem. 2007. PMID: 17948975
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