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Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.
Lupien M, Jeyakumar M, Hébert E, Hilmi K, Cotnoir-White D, Loch C, Auger A, Dayan G, Pinard GA, Wurtz JM, Moras D, Katzenellenbogen J, Mader S. Lupien M, et al. Among authors: pinard ga. Mol Endocrinol. 2007 Apr;21(4):797-816. doi: 10.1210/me.2006-0074. Epub 2007 Feb 13. Mol Endocrinol. 2007. PMID: 17299137