Hamilton A - Search Results

1

Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.

Epifano F, Curini M, Genovese S, Blaskovich M, Hamilton A, Sebti SM. Epifano F, et al. Among authors: hamilton a. Bioorg Med Chem Lett. 2007 May 1;17(9):2639-42. doi: 10.1016/j.bmcl.2007.01.097. Epub 2007 Feb 2. Bioorg Med Chem Lett. 2007. PMID: 17314046

2

Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.

Carrico D, Blaskovich MA, Bucher CJ, Sebti SM, Hamilton AD. Carrico D, et al. Among authors: hamilton ad. Bioorg Med Chem. 2005 Feb 1;13(3):677-88. doi: 10.1016/j.bmc.2004.10.053. Bioorg Med Chem. 2005. PMID: 15653335

3

Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics.

Kayser KJ, Glenn MP, Sebti SM, Cheng JQ, Hamilton AD. Kayser KJ, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2068-73. doi: 10.1016/j.bmcl.2007.01.004. Epub 2007 Jan 12. Bioorg Med Chem Lett. 2007. PMID: 17276059

4

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.

Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Gunning PT, et al. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1875-8. doi: 10.1016/j.bmcl.2007.01.077. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17336521

5

Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents.

Kayser-Bricker KJ, Glenn MP, Lee SH, Sebti SM, Cheng JQ, Hamilton AD. Kayser-Bricker KJ, et al. Bioorg Med Chem. 2009 Feb 15;17(4):1764-71. doi: 10.1016/j.bmc.2008.09.058. Epub 2008 Sep 27. Bioorg Med Chem. 2009. PMID: 19179081 Free PMC article.

6

Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.

Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Fletcher S, et al. Among authors: hamilton ad. J Med Chem. 2010 Oct 14;53(19):6867-88. doi: 10.1021/jm1001748. J Med Chem. 2010. PMID: 20822181 Free PMC article.

7

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.

Ohkanda J, Lockman JW, Kothare MA, Qian Y, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: hamilton ad. J Med Chem. 2002 Jan 3;45(1):177-88. doi: 10.1021/jm0103099. J Med Chem. 2002. PMID: 11754590

8

Inhibitors of protein farnesyltransferase as novel anticancer agents.

Ohkanda J, Knowles DB, Blaskovich MA, Sebti SM, Hamilton AD. Ohkanda J, et al. Among authors: hamilton ad. Curr Top Med Chem. 2002 Mar;2(3):303-23. doi: 10.2174/1568026023394281. Curr Top Med Chem. 2002. PMID: 11944822 Review.

9

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.

Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. Carrico D, et al. Among authors: hamilton ad. Bioorg Med Chem. 2004 Dec 15;12(24):6517-26. doi: 10.1016/j.bmc.2004.09.020. Bioorg Med Chem. 2004. PMID: 15556768

10

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.

Qian Y, Vogt A, Sebti SM, Hamilton AD. Qian Y, et al. Among authors: hamilton ad. J Med Chem. 1996 Jan 5;39(1):217-23. doi: 10.1021/jm950414g. J Med Chem. 1996. PMID: 8568811

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