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Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT1A1, 1A3 and 1A8.
Muzeeb S, Basha SJ, Shashikumar D, Mullangi R, Srinivas NR. Muzeeb S, et al. Among authors: mullangi r. Eur J Drug Metab Pharmacokinet. 2006 Oct-Dec;31(4):299-309. doi: 10.1007/BF03190471. Eur J Drug Metab Pharmacokinet. 2006. PMID: 17315542
Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats.
Mamidi RN, Mullangi R, Kota J, Bhamidipati R, Khan AA, Katneni K, Datla S, Singh SK, Rao KY, Rao CS, Srinivas NR, Rajagopalan R. Mamidi RN, et al. Among authors: mullangi r. Biopharm Drug Dispos. 2002 Oct;23(7):273-82. doi: 10.1002/bdd.319. Biopharm Drug Dispos. 2002. PMID: 12355578
Development and validation of a chiral liquid chromatographic method, based on Chiralpak to quantify enantiomers of (+/-)-DRF 2725 in rat plasma: lack of inversion of ragaglitazar (S(-)-DRF 2725) to its antipode in plasma.
Mustafa SS, Trivedi R, Mamidi NV, Mullangi R, Srinivas NR. Mustafa SS, et al. Among authors: mullangi r. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Sep 25;809(1):23-30. doi: 10.1016/j.jchromb.2004.05.030. J Chromatogr B Analyt Technol Biomed Life Sci. 2004. PMID: 15282089
2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.
Singh SK, Vobbalareddy S, Kalleda SR, Rajjak SA, Casturi SR, Datla SR, Mamidi RN, Mullangi R, Bhamidipati R, Ramanujam R, Akella V, Yeleswarapu KR. Singh SK, et al. Among authors: mullangi r. Org Biomol Chem. 2004 Sep 7;2(17):2442-50. doi: 10.1039/B402787F. Epub 2004 Aug 11. Org Biomol Chem. 2004. PMID: 15326524
194 results