Xu W - Search Results

1

The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase.

Whitlow M, Adler M, Davey D, Huang Q, Koovakkat S, Parkinson JF, Pham E, Polokoff M, Xu W, Yuan S, Phillips G. Whitlow M, et al. Among authors: xu w. Bioorg Med Chem Lett. 2007 May 1;17(9):2505-8. doi: 10.1016/j.bmcl.2007.02.018. Epub 2007 Feb 9. Bioorg Med Chem Lett. 2007. PMID: 17336523

2

Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups.

Phillips G, Guilford WJ, Buckman BO, Davey DD, Eagen KA, Koovakkat S, Liang A, McCarrick M, Mohan R, Ng HP, Pinkerton M, Subramanyam B, Ho E, Trinh L, Whitlow M, Wu S, Xu W, Morrissey MM. Phillips G, et al. Among authors: xu w. J Med Chem. 2002 Jun 6;45(12):2484-93. doi: 10.1021/jm0200660. J Med Chem. 2002. PMID: 12036356

3

1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.

Wei RG, Adler M, Davey D, Ho E, Mohan R, Polokoff M, Tseng JL, Whitlow M, Xu W, Yuan S, Phillips G. Wei RG, et al. Among authors: xu w. Bioorg Med Chem Lett. 2007 May 1;17(9):2499-504. doi: 10.1016/j.bmcl.2007.02.053. Epub 2007 Feb 27. Bioorg Med Chem Lett. 2007. PMID: 17368901

4

Design and synthesis of aminophenol-based factor Xa inhibitors.

Wu S, Guilford WJ, Chou YL, Griedel BD, Liang A, Sakata S, Shaw KJ, Trinh L, Xu W, Zhao Z, Morrissey MM. Wu S, et al. Among authors: xu w. Bioorg Med Chem Lett. 2002 May 6;12(9):1307-10. doi: 10.1016/s0960-894x(02)00142-7. Bioorg Med Chem Lett. 2002. PMID: 11965377

5

Reversible, orally available ADP receptor (P2Y₁₂) antagonists Part I: Hit to lead process.

Islam I, Yuan S, Wei RG, Xu W, Morrissey M, Mohan R, Zheng D, DiMella A, Dunning L, Snider M, Subramanyam B, Tseng JL, Bryant JA, Buckman BO. Islam I, et al. Among authors: xu w. Bioorg Med Chem Lett. 2018 May 15;28(9):1459-1463. doi: 10.1016/j.bmcl.2018.03.090. Epub 2018 Mar 31. Bioorg Med Chem Lett. 2018. PMID: 29628327

6

The design, synthesis, and biological evaluation of PIM kinase inhibitors.

Tsuhako AL, Brown DS, Koltun ES, Aay N, Arcalas A, Chan V, Du H, Engst S, Franzini M, Galan A, Huang P, Johnston S, Kane B, Kim MH, Laird AD, Lin R, Mock L, Ngan I, Pack M, Stott G, Stout TJ, Yu P, Zaharia C, Zhang W, Zhou P, Nuss JM, Kearney PC, Xu W. Tsuhako AL, et al. Among authors: xu w. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3732-8. doi: 10.1016/j.bmcl.2012.04.025. Epub 2012 Apr 11. Bioorg Med Chem Lett. 2012. PMID: 22542012

7

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors.

Kim MH, Tsuhako AL, Co EW, Aftab DT, Bentzien F, Chen J, Cheng W, Engst S, Goon L, Klein RR, Le DT, Mac M, Parks JJ, Qian F, Rodriquez M, Stout TJ, Till JH, Won KA, Wu X, Yakes FM, Yu P, Zhang W, Zhao Y, Lamb P, Nuss JM, Xu W. Kim MH, et al. Among authors: xu w. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. doi: 10.1016/j.bmcl.2012.06.029. Epub 2012 Jun 16. Bioorg Med Chem Lett. 2012. PMID: 22765894

8

Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface.

Ren J, Xu W, Tang L, Su M, Chen D, Chen YL, Zang Y, Li J, Shen J, Zhou Y, Xiong B. Ren J, et al. Among authors: xu w. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-4476. doi: 10.1016/j.bmcl.2016.07.074. Epub 2016 Aug 2. Bioorg Med Chem Lett. 2016. PMID: 27528435

9

Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity.

Shaw KJ, Guilford WJ, Griedel BD, Sakata S, Trinh L, Wu S, Xu W, Zhao Z, Morrissey MM. Shaw KJ, et al. Among authors: xu w. Bioorg Med Chem Lett. 2002 May 6;12(9):1311-4. doi: 10.1016/s0960-894x(02)00145-2. Bioorg Med Chem Lett. 2002. PMID: 11965378

10

Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors.

Bussenius J, Anand NK, Blazey CM, Bowles OJ, Bannen LC, Chan DS, Chen B, Co EW, Costanzo S, DeFina SC, Dubenko L, Engst S, Franzini M, Huang P, Jammalamadaka V, Khoury RG, Kim MH, Klein RR, Laird D, Le DT, Mac MB, Matthews DJ, Markby D, Miller N, Nuss JM, Parks JJ, Tsang TH, Tsuhako AL, Wang Y, Xu W, Rice KD. Bussenius J, et al. Among authors: xu w. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2283-6. doi: 10.1016/j.bmcl.2012.01.105. Epub 2012 Feb 2. Bioorg Med Chem Lett. 2012. PMID: 22342124

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