Breton R - Search Results

1

Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens.

Roy J, Breton R, Martel C, Labrie F, Poirier D. Roy J, et al. Among authors: breton r. Bioorg Med Chem. 2007 Apr 15;15(8):3003-18. doi: 10.1016/j.bmc.2007.02.007. Epub 2007 Feb 13. Bioorg Med Chem. 2007. PMID: 17336533

2

Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12.

Cantin L, Faucher F, Couture JF, de Jésus-Tran KP, Legrand P, Ciobanu LC, Fréchette Y, Labrecque R, Singh SM, Labrie F, Breton R. Cantin L, et al. Among authors: breton r. J Biol Chem. 2007 Oct 19;282(42):30910-9. doi: 10.1074/jbc.M705524200. Epub 2007 Aug 21. J Biol Chem. 2007. PMID: 17711855 Free article.

3

Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.

Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX. Nahoum V, et al. Among authors: breton r. J Biol Chem. 2001 Nov 9;276(45):42091-8. doi: 10.1074/jbc.M105610200. Epub 2001 Aug 20. J Biol Chem. 2001. PMID: 11514561 Free article.

4

Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen.

Couture JF, de Jésus-Tran KP, Roy AM, Cantin L, Côté PL, Legrand P, Luu-The V, Labrie F, Breton R. Couture JF, et al. Among authors: breton r. Protein Sci. 2005 Jun;14(6):1485-97. doi: 10.1110/ps.051353205. Protein Sci. 2005. PMID: 15929998 Free PMC article.

5

Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.

Pereira de Jésus-Tran K, Côté PL, Cantin L, Blanchet J, Labrie F, Breton R. Pereira de Jésus-Tran K, et al. Among authors: breton r. Protein Sci. 2006 May;15(5):987-99. doi: 10.1110/ps.051905906. Protein Sci. 2006. PMID: 16641486 Free PMC article.

6

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

Faucher F, Cantin L, Pereira de Jésus-Tran K, Lemieux M, Luu-The V, Labrie F, Breton R. Faucher F, et al. Among authors: breton r. J Mol Biol. 2007 Jun 1;369(2):525-40. doi: 10.1016/j.jmb.2007.03.058. Epub 2007 Mar 27. J Mol Biol. 2007. PMID: 17442338

7

Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates.

Couture JF, Cantin L, Legrand P, Luu-The V, Labrie F, Breton R. Couture JF, et al. Among authors: breton r. Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):135-9. doi: 10.1107/s0907444901017346. Epub 2001 Dec 21. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11752791

8

Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.

Couture JF, Legrand P, Cantin L, Luu-The V, Labrie F, Breton R. Couture JF, et al. Among authors: breton r. J Mol Biol. 2003 Aug 15;331(3):593-604. doi: 10.1016/s0022-2836(03)00762-9. J Mol Biol. 2003. PMID: 12899831

9

Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.

Couture JF, Legrand P, Cantin L, Labrie F, Luu-The V, Breton R. Couture JF, et al. Among authors: breton r. J Mol Biol. 2004 May 21;339(1):89-102. doi: 10.1016/j.jmb.2004.03.035. J Mol Biol. 2004. PMID: 15123423

10

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

Faucher F, Pereira de Jésus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R. Faucher F, et al. Among authors: breton r. J Mol Biol. 2006 Dec 8;364(4):747-63. doi: 10.1016/j.jmb.2006.09.030. Epub 2006 Sep 16. J Mol Biol. 2006. PMID: 17034817

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