Pinedo HM - Search Results

1

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.

Giovannetti E, Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Poupon MF, Azzarello A, Pinedo HM, Peters GJ. Giovannetti E, et al. Among authors: pinedo hm. Br J Cancer. 2007 Mar 12;96(5):769-75. doi: 10.1038/sj.bjc.6603639. Br J Cancer. 2007. PMID: 17339891 Free PMC article.

2

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer.

Mauritz R, van Groeningen CJ, Smid K, Jansen G, Pinedo HM, Peters GJ. Mauritz R, et al. Among authors: pinedo hm. Int J Cancer. 2007 Jun 15;120(12):2609-12. doi: 10.1002/ijc.22626. Int J Cancer. 2007. PMID: 17330233

3

Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.

Mauritz R, Giovannetti E, Beumer IJ, Smid K, Van Groeningen CJ, Pinedo HM, Peters GJ. Mauritz R, et al. Among authors: pinedo hm. Clin Colorectal Cancer. 2009 Jul;8(3):146-54. doi: 10.3816/CCC.2009.n.024. Clin Colorectal Cancer. 2009. PMID: 19632929

4

Thymidylate synthase and drug resistance.

Peters GJ, van der Wilt CL, van Triest B, Codacci-Pisanelli G, Johnston PG, van Groeningen CJ, Pinedo HM. Peters GJ, et al. Among authors: pinedo hm. Eur J Cancer. 1995 Jul-Aug;31A(7-8):1299-305. doi: 10.1016/0959-8049(95)00172-f. Eur J Cancer. 1995. PMID: 7577040 Free article. Review.

5

Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.

Peters GJ, Smitskamp-Wilms E, Smid K, Pinedo HM, Jansen G. Peters GJ, et al. Among authors: pinedo hm. Cancer Res. 1999 Nov 1;59(21):5529-35. Cancer Res. 1999. PMID: 10554030

6

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.

Peters GJ, van Triest B, Backus HH, Kuiper CM, van der Wilt CL, Pinedo HM. Peters GJ, et al. Among authors: pinedo hm. Eur J Cancer. 2000 May;36(7):916-24. doi: 10.1016/s0959-8049(00)00026-5. Eur J Cancer. 2000. PMID: 10785598

7

Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody.

Van Triest B, Loftus BM, Pinedo HM, Backus HH, Schoenmakers P, Telleman F, Tadema T, Aherne GW, Van Groeningen CJ, Zoetmulder FA, Taal BG, Johnston PG, Peters GJ. Van Triest B, et al. Among authors: pinedo hm. J Histochem Cytochem. 2000 Jun;48(6):755-60. doi: 10.1177/002215540004800604. J Histochem Cytochem. 2000. PMID: 10820149

8

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

Van Triest B, Pinedo HM, Giaccone G, Peters GJ. Van Triest B, et al. Among authors: pinedo hm. Ann Oncol. 2000 Apr;11(4):385-91. doi: 10.1023/a:1008351221345. Ann Oncol. 2000. PMID: 10847455 Free article. Review.

9

Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.

Backus HH, Pinedo HM, Wouters D, Padrón JM, Molders N, van Der Wilt CL, van Groeningen CJ, Jansen G, Peters GJ. Backus HH, et al. Among authors: pinedo hm. Int J Cancer. 2000 Sep 15;87(6):771-8. doi: 10.1002/1097-0215(20000915)87:6<771::aid-ijc2>3.0.co;2-v. Int J Cancer. 2000. PMID: 10956384

10

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.

Backus HH, Pinedo HM, Wouters D, Kuiper CM, Jansen G, van Groeningen CJ, Peters GJ. Backus HH, et al. Among authors: pinedo hm. Oncol Res. 2000;12(5):231-9. doi: 10.3727/096504001108747729. Oncol Res. 2000. PMID: 11417748

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