Wouters D - Search Results

1

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.

Giovannetti E, Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Poupon MF, Azzarello A, Pinedo HM, Peters GJ. Giovannetti E, et al. Among authors: wouters d. Br J Cancer. 2007 Mar 12;96(5):769-75. doi: 10.1038/sj.bjc.6603639. Br J Cancer. 2007. PMID: 17339891 Free PMC article.

2

Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.

Backus HH, Pinedo HM, Wouters D, Padrón JM, Molders N, van Der Wilt CL, van Groeningen CJ, Jansen G, Peters GJ. Backus HH, et al. Among authors: wouters d. Int J Cancer. 2000 Sep 15;87(6):771-8. doi: 10.1002/1097-0215(20000915)87:6<771::aid-ijc2>3.0.co;2-v. Int J Cancer. 2000. PMID: 10956384

3

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients.

Backus HH, Dukers DF, van Groeningen CJ, Vos W, Bloemena E, Wouters D, van Riel JM, Smid K, Giaccone G, Pinedo HM, Peters GJ. Backus HH, et al. Among authors: wouters d. Ann Oncol. 2001 Feb;12(2):209-16. doi: 10.1023/a:1008331525368. Ann Oncol. 2001. PMID: 11300326 Free article.

4

Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.

van der Wilt CL, Backus HH, Smid K, Comijn L, Veerman G, Wouters D, Voorn DA, Priest DG, Bunni MA, Mitchell F, Jackman AL, Jansen G, Peters GJ. van der Wilt CL, et al. Among authors: wouters d. Cancer Res. 2001 May 1;61(9):3675-81. Cancer Res. 2001. PMID: 11325838

5

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.

Backus HH, Pinedo HM, Wouters D, Kuiper CM, Jansen G, van Groeningen CJ, Peters GJ. Backus HH, et al. Among authors: wouters d. Oncol Res. 2000;12(5):231-9. doi: 10.3727/096504001108747729. Oncol Res. 2000. PMID: 11417748

6

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer.

Backus HH, van Riel JM, van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Peters GJ. Backus HH, et al. Among authors: wouters d. Ann Oncol. 2001 Jun;12(6):779-85. doi: 10.1023/a:1011112227044. Ann Oncol. 2001. PMID: 11484952 Free article.

7

Thymidylate synthase inhibition induces p53 dependent and independent cell death.

Backus HH, Wouters D, van der Wilt CL, Kuiper CM, van Groeningen CJ, Pinedo HM, Peters GJ. Backus HH, et al. Among authors: wouters d. Adv Exp Med Biol. 2000;486:303-6. doi: 10.1007/0-306-46843-3_59. Adv Exp Med Biol. 2000. PMID: 11783505 No abstract available.

8

Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases.

Backus HH, Van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Peters GJ. Backus HH, et al. Among authors: wouters d. J Clin Pathol. 2002 Mar;55(3):206-11. doi: 10.1136/jcp.55.3.206. J Clin Pathol. 2002. PMID: 11896073 Free PMC article.

9

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.

Backus HH, Wouters D, Ferreira CG, van Houten VM, Brakenhoff RH, Pinedo HM, Peters GJ. Backus HH, et al. Among authors: wouters d. Eur J Cancer. 2003 Jun;39(9):1310-7. doi: 10.1016/s0959-8049(03)00204-1. Eur J Cancer. 2003. PMID: 12763222

10

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.

Sigmond J, Backus HH, Wouters D, Temmink OH, Jansen G, Peters GJ. Sigmond J, et al. Among authors: wouters d. Biochem Pharmacol. 2003 Aug 1;66(3):431-8. doi: 10.1016/s0006-2952(03)00287-9. Biochem Pharmacol. 2003. PMID: 12907242

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