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Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling.
Lavrik IN, Golks A, Riess D, Bentele M, Eils R, Krammer PH. Lavrik IN, et al. J Biol Chem. 2007 May 4;282(18):13664-71. doi: 10.1074/jbc.M700434200. Epub 2007 Mar 8. J Biol Chem. 2007. PMID: 17347143 Free article.
Recently we generated a mathematical model (Bentele, M., Lavrik, I., Ulrich, M., Stosser, S., Heermann, D. W., Kalthoff, H., Krammer, P. H., and Eils, R. (2004) J. Cell Biol. 166, 839-851) of signaling in CD95(Fas/APO-1)-mediated apoptosis. Mathematical modeling …
Recently we generated a mathematical model (Bentele, M., Lavrik, I., Ulrich, M., Stosser, S., Heermann, D. W., Kalthoff, H., Krammer, …
Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection.
Antropova EA, Khlebodarova TM, Demenkov PS, Volianskaia AR, Venzel AS, Ivanisenko NV, Gavrilenko AD, Ivanisenko TV, Adamovskaya AV, Revva PM, Kolchanov NA, Lavrik IN, Ivanisenko VA. Antropova EA, et al. Among authors: lavrik in. J Integr Bioinform. 2023 Nov 20;20(3):20230013. doi: 10.1515/jib-2023-0013. eCollection 2023 Sep 1. J Integr Bioinform. 2023. PMID: 37978846 Free PMC article.
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly … See abstract for full author list ➔ Vitale I, et al. Among authors: lavrik in. Cell Death Differ. 2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26. Cell Death Differ. 2023. PMID: 37100955 Free PMC article. Review.
The active caspase-8 heterotetramer is formed at the CD95 DISC.
Lavrik I, Krueger A, Schmitz I, Baumann S, Weyd H, Krammer PH, Kirchhoff S. Lavrik I, et al. Cell Death Differ. 2003 Jan;10(1):144-5. doi: 10.1038/sj.cdd.4401156. Cell Death Differ. 2003. PMID: 12655304 No abstract available.
Death receptor signaling.
Lavrik I, Golks A, Krammer PH. Lavrik I, et al. J Cell Sci. 2005 Jan 15;118(Pt 2):265-7. doi: 10.1242/jcs.01610. J Cell Sci. 2005. PMID: 15654015 Review. No abstract available.
c-FLIPR, a new regulator of death receptor-induced apoptosis.
Golks A, Brenner D, Fritsch C, Krammer PH, Lavrik IN. Golks A, et al. Among authors: lavrik in. J Biol Chem. 2005 Apr 15;280(15):14507-13. doi: 10.1074/jbc.M414425200. Epub 2005 Feb 8. J Biol Chem. 2005. PMID: 15701649 Free article.
115 results