Gasparini F - Search Results

1

Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.

Marinozzi M, Serpi M, Amori L, Gavilan Diaz M, Costantino G, Meyer U, Flor PJ, Gasparini F, Heckendorn R, Kuhn R, Giorgi G, Hermit MB, Thomsen C, Pellicciari R. Marinozzi M, et al. Among authors: gasparini f. Bioorg Med Chem. 2007 May 1;15(9):3161-70. doi: 10.1016/j.bmc.2007.02.040. Epub 2007 Feb 22. Bioorg Med Chem. 2007. PMID: 17350267

2

Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III.

Amori L, Costantino G, Marinozzi M, Pellicciari R, Gasparini F, Flor PJ, Kuhn R, Vranesic I. Amori L, et al. Among authors: gasparini f. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1447-50. doi: 10.1016/s0960-894x(00)00247-x. Bioorg Med Chem Lett. 2000. PMID: 10888329

3

Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.

Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Amori L, Josef Flor P, Gasparini F, Kuhn R, Urwyler S. Pellicciari R, et al. Among authors: gasparini f. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3179-82. doi: 10.1016/s0960-894x(01)00656-4. Bioorg Med Chem Lett. 2001. PMID: 11720869

4

Spiro[2.2]pentane as a dissymmetric scaffold for conformationally constrained analogues of glutamic acid: focus on racemic 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.

Pellicciari R, Marinozzi M, Camaioni E, del Carmen Nùnez M, Costantino G, Gasparini F, Giorgi G, Macchiarulo A, Subramanian N. Pellicciari R, et al. Among authors: gasparini f. J Org Chem. 2002 Aug 9;67(16):5497-507. doi: 10.1021/jo020138v. J Org Chem. 2002. PMID: 12153247

5

[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

Gasparini F, Andres H, Flor PJ, Heinrich M, Inderbitzin W, Lingenhöhl K, Müller H, Munk VC, Omilusik K, Stierlin C, Stoehr N, Vranesic I, Kuhn R. Gasparini F, et al. Bioorg Med Chem Lett. 2002 Feb 11;12(3):407-9. doi: 10.1016/s0960-894x(01)00767-3. Bioorg Med Chem Lett. 2002. PMID: 11814808

6

(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.

Gasparini F, Inderbitzin W, Francotte E, Lecis G, Richert P, Dragic Z, Kuhn R, Flor PJ. Gasparini F, et al. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1241-4. doi: 10.1016/s0960-894x(00)00197-9. Bioorg Med Chem Lett. 2000. PMID: 10866390

7

AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization.

Vranesic I, Ofner S, Flor PJ, Bilbe G, Bouhelal R, Enz A, Desrayaud S, McAllister K, Kuhn R, Gasparini F. Vranesic I, et al. Among authors: gasparini f. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803. doi: 10.1016/j.bmc.2014.09.033. Epub 2014 Sep 20. Bioorg Med Chem. 2014. PMID: 25316499

8

Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester.

Ott D, Floersheim P, Inderbitzin W, Stoehr N, Francotte E, Lecis G, Richert P, Rihs G, Flor PJ, Kuhn R, Gasparini F. Ott D, et al. Among authors: gasparini f. J Med Chem. 2000 Nov 16;43(23):4428-36. doi: 10.1021/jm0009944. J Med Chem. 2000. PMID: 11087567

9

Neuroprotective activity of metabotropic glutamate receptor ligands.

Flor PJ, Battaglia G, Nicoletti F, Gasparini F, Bruno V. Flor PJ, et al. Among authors: gasparini f. Adv Exp Med Biol. 2002;513:197-223. doi: 10.1007/978-1-4615-0123-7_7. Adv Exp Med Biol. 2002. PMID: 12575822 Review.

10

Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death.

Bruno V, Battaglia G, Ksiazek I, van der Putten H, Catania MV, Giuffrida R, Lukic S, Leonhardt T, Inderbitzin W, Gasparini F, Kuhn R, Hampson DR, Nicoletti F, Flor PJ. Bruno V, et al. Among authors: gasparini f. J Neurosci. 2000 Sep 1;20(17):6413-20. doi: 10.1523/JNEUROSCI.20-17-06413.2000. J Neurosci. 2000. PMID: 10964947 Free PMC article.

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