Klein C - Search Results

1

Exploratory study comparing the metabolic toxicities of a lopinavir/ritonavir plus saquinavir dual protease inhibitor regimen versus a lopinavir/ritonavir plus zidovudine/lamivudine nucleoside regimen.

Cameron DW, Becker S, King MS, da Silva B, Klein C, Tokimoto D, Foit C, Calhoun D, Bernstein B, Hanna GJ. Cameron DW, et al. Among authors: klein c. J Antimicrob Chemother. 2007 May;59(5):957-63. doi: 10.1093/jac/dkm029. Epub 2007 Mar 9. J Antimicrob Chemother. 2007. PMID: 17350990 Clinical Trial.

2

High-dose lopinavir/ritonavir in highly treatment-experienced HIV-1 patients: efficacy, safety, and predictors of response.

Podzamczer D, King MS, Klein CE, Flexner C, Katlama C, Havlir DV, Letendre SL, Eron JJ, Brun SC, Bernstein B. Podzamczer D, et al. Among authors: klein ce. HIV Clin Trials. 2007 Jul-Aug;8(4):193-204. doi: 10.1310/hct0804-193. HIV Clin Trials. 2007. PMID: 17720659 Clinical Trial.

3

Predictors of loss of virologic response in subjects who simplified to lopinavir/ritonavir monotherapy from lopinavir/ritonavir plus zidovudine/lamivudine.

Campo RE, Da Silva BA, Cotte L, Gathe JC, Gazzard B, Hicks CB, Klein CE, Chiu YL, King MS, Bernstein BM. Campo RE, et al. Among authors: klein ce. AIDS Res Hum Retroviruses. 2009 Mar;25(3):269-75. doi: 10.1089/aid.2008.0217. AIDS Res Hum Retroviruses. 2009. PMID: 19292590 Clinical Trial.

4

The tablet formulation of lopinavir/ritonavir provides similar bioavailability to the soft-gelatin capsule formulation with less pharmacokinetic variability and diminished food effect.

Klein CE, Chiu YL, Awni W, Zhu T, Heuser RS, Doan T, Breitenbach J, Morris JB, Brun SC, Hanna GJ. Klein CE, et al. J Acquir Immune Defic Syndr. 2007 Apr 1;44(4):401-10. doi: 10.1097/QAI.0b013e31803133c5. J Acquir Immune Defic Syndr. 2007. PMID: 17224848 Clinical Trial.

5

Effects of acid-reducing agents on the pharmacokinetics of lopinavir/ritonavir and ritonavir-boosted atazanavir.

Klein CE, Chiu YL, Cai Y, Beck K, King KR, Causemaker SJ, Doan T, Esslinger HU, Podsadecki TJ, Hanna GJ. Klein CE, et al. J Clin Pharmacol. 2008 May;48(5):553-62. doi: 10.1177/0091270007313392. J Clin Pharmacol. 2008. PMID: 18440920 Clinical Trial.

6

Pharmacokinetics and safety of the lopinavir/ritonavir tablet 500/125 mg twice daily coadministered with efavirenz in healthy adult participants.

Ng J, Chiu YL, Awni W, Bernstein B, Causemaker SJ, Klein CE. Ng J, et al. J Clin Pharmacol. 2012 Aug;52(8):1248-54. doi: 10.1177/0091270011410568. Epub 2011 Jun 30. J Clin Pharmacol. 2012. PMID: 21719718

7

No Need for Lopinavir Dose Adjustment during Pregnancy: a Population Pharmacokinetic and Exposure-Response Analysis in Pregnant and Nonpregnant HIV-Infected Subjects.

Salem AH, Jones AK, Santini-Oliveira M, Taylor GP, Patterson KB, Nilius AM, Klein CE. Salem AH, et al. Antimicrob Agents Chemother. 2015 Nov 2;60(1):400-8. doi: 10.1128/AAC.01197-15. Print 2016 Jan. Antimicrob Agents Chemother. 2015. PMID: 26525798 Free PMC article. Clinical Trial.

8

Lack of effect of gastric acid-reducing agents on the pharmacokinetics of lopinavir/ritonavir in HIV-infected patients.

Chiu YL, Klein CE, Woodward WC, King KR, Naylor C, Awni W, Brun S. Chiu YL, et al. Among authors: klein ce. AIDS Patient Care STDS. 2007 Apr;21(4):247-51. doi: 10.1089/apc.2006.0120. AIDS Patient Care STDS. 2007. PMID: 17461719

9

Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavir.

Kempf DJ, Klein C, Chen HJ, Klein LL, Yeung C, Randolph JT, Lau YY, Chovan LE, Guan Z, Hernandez L, Turner TM, Dandliker PJ, Marsh KC. Kempf DJ, et al. Among authors: klein ll, klein c. Antivir Chem Chemother. 2007;18(3):163-7. doi: 10.1177/095632020701800306. Antivir Chem Chemother. 2007. PMID: 17626600 Free article.

10

Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers.

Yeh RF, Gaver VE, Patterson KB, Rezk NL, Baxter-Meheux F, Blake MJ, Eron JJ Jr, Klein CE, Rublein JC, Kashuba AD. Yeh RF, et al. Among authors: klein ce. J Acquir Immune Defic Syndr. 2006 May;42(1):52-60. doi: 10.1097/01.qai.0000219774.20174.64. J Acquir Immune Defic Syndr. 2006. PMID: 16639344

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