Mani N - Search Results

1

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis.

Gomez L, Hack MD, Wu J, Wiener JJ, Venkatesan H, Santillán A Jr, Pippel DJ, Mani N, Morrow BJ, Motley ST, Shaw KJ, Wolin R, Grice CA, Jones TK. Gomez L, et al. Among authors: mani n. Bioorg Med Chem Lett. 2007 May 15;17(10):2723-7. doi: 10.1016/j.bmcl.2007.03.003. Epub 2007 Mar 6. Bioorg Med Chem Lett. 2007. PMID: 17368897

2

Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: part 1.

Lee-Dutra A, Wiener DK, Arienti KL, Liu J, Mani N, Ameriks MK, Axe FU, Gebauer D, Desai PJ, Nguyen S, Randal M, Thurmond RL, Sun S, Karlsson L, Edwards JP, Jones TK, Grice CA. Lee-Dutra A, et al. Among authors: mani n. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2370-4. doi: 10.1016/j.bmcl.2010.01.108. Epub 2010 Jan 28. Bioorg Med Chem Lett. 2010. PMID: 20153648

3

A scalable synthesis of a histamine H3 receptor antagonist.

Mani NS, Jablonowski JA, Jones TK. Mani NS, et al. J Org Chem. 2004 Nov 12;69(23):8115-7. doi: 10.1021/jo040225i. J Org Chem. 2004. PMID: 15527300

4

Stereoselective synthesis of Z-alpha-aryl-alpha,beta-unsaturated esters.

Mani NS, Mapes CM, Wu J, Deng X, Jones TK. Mani NS, et al. J Org Chem. 2006 Jun 23;71(13):5039-42. doi: 10.1021/jo060586t. J Org Chem. 2006. PMID: 16776544

5

Reactions between Weinreb amides and 2-magnesiated oxazoles: a simple and efficient preparation of 2-acyl oxazoles.

Pippel DJ, Mapes CM, Mani NS. Pippel DJ, et al. J Org Chem. 2007 Jul 20;72(15):5828-31. doi: 10.1021/jo070646a. Epub 2007 Jun 22. J Org Chem. 2007. PMID: 17585818

6

Design of concise, scalable route to a cholecystokinin 1 (CCK 1) receptor antagonist.

Liang JT, Mani NS, Jones TK. Liang JT, et al. J Org Chem. 2007 Oct 26;72(22):8243-50. doi: 10.1021/jo071166m. Epub 2007 Sep 22. J Org Chem. 2007. PMID: 17887796

7

Practical and scalable synthesis of a selective CCK1 receptor antagonist.

Mapes CM, Mani NS, Deng X, Pandit CR, McClure KJ, Pippel MC, Sehon CA, Gomez L, Shinde S, Breitenbucher JG, Jones TK. Mapes CM, et al. J Org Chem. 2010 Nov 19;75(22):7950-3. doi: 10.1021/jo1017684. Epub 2010 Oct 27. J Org Chem. 2010. PMID: 20977279

8

Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability.

Deng X, Sun S, Wu J, Kuei C, Joseph V, Liu C, Mani NS. Deng X, et al. Bioorg Med Chem Lett. 2016 Oct 15;26(20):4888-4891. doi: 10.1016/j.bmcl.2016.09.029. Epub 2016 Sep 12. Bioorg Med Chem Lett. 2016. PMID: 27658369

9

Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.

Letavic MA, Bonaventure P, Carruthers NI, Dugovic C, Koudriakova T, Lord B, Lovenberg TW, Ly KS, Mani NS, Nepomuceno D, Pippel DJ, Rizzolio M, Shelton JE, Shah CR, Shireman BT, Young LK, Yun S. Letavic MA, et al. J Med Chem. 2015 Jul 23;58(14):5620-36. doi: 10.1021/acs.jmedchem.5b00742. Epub 2015 Jul 8. J Med Chem. 2015. PMID: 26087021

10

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.

Préville C, Bonaventure P, Koudriakova T, Lord B, Nepomuceno D, Rizzolio M, Mani N, Coe KJ, Ndifor A, Dugovic C, Dvorak CA, Coate H, Pippel DJ, Fitzgerald A, Allison B, Lovenberg TW, Carruthers NI, Shireman BT. Préville C, et al. Among authors: mani n. ACS Med Chem Lett. 2020 Apr 27;11(10):2002-2009. doi: 10.1021/acsmedchemlett.0c00085. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062185 Free PMC article.

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