Lee RE - Search Results

1

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

Zhang YM, Chohnan S, Virga KG, Stevens RD, Ilkayeva OR, Wenner BR, Bain JR, Newgard CB, Lee RE, Rock CO, Jackowski S. Zhang YM, et al. Among authors: lee re. Chem Biol. 2007 Mar;14(3):291-302. doi: 10.1016/j.chembiol.2007.01.013. Chem Biol. 2007. PMID: 17379144 Free PMC article.

2

The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.

Ivey RA, Zhang YM, Virga KG, Hevener K, Lee RE, Rock CO, Jackowski S, Park HW. Ivey RA, et al. Among authors: lee re. J Biol Chem. 2004 Aug 20;279(34):35622-9. doi: 10.1074/jbc.M403152200. Epub 2004 May 10. J Biol Chem. 2004. PMID: 15136582 Free article.

3

Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.

Zhang YM, Frank MW, Virga KG, Lee RE, Rock CO, Jackowski S. Zhang YM, et al. Among authors: lee re. J Biol Chem. 2004 Dec 3;279(49):50969-75. doi: 10.1074/jbc.M409607200. Epub 2004 Sep 30. J Biol Chem. 2004. PMID: 15459190 Free article.

4

A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.

Leonardi R, Chohnan S, Zhang YM, Virga KG, Lee RE, Rock CO, Jackowski S. Leonardi R, et al. Among authors: lee re. J Biol Chem. 2005 Feb 4;280(5):3314-22. doi: 10.1074/jbc.M411608200. Epub 2004 Nov 17. J Biol Chem. 2005. PMID: 15548531 Free article.

5

Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes.

Welch KT, Virga KG, Whittemore NA, Ozen C, Wright E, Brown CL, Lee RE, Serpersu EH. Welch KT, et al. Among authors: lee re. Bioorg Med Chem. 2005 Nov 15;13(22):6252-63. doi: 10.1016/j.bmc.2005.06.059. Bioorg Med Chem. 2005. PMID: 16140014

6

Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.

Virga KG, Zhang YM, Leonardi R, Ivey RA, Hevener K, Park HW, Jackowski S, Rock CO, Lee RE. Virga KG, et al. Among authors: lee re. Bioorg Med Chem. 2006 Feb 15;14(4):1007-20. doi: 10.1016/j.bmc.2005.09.021. Epub 2005 Oct 5. Bioorg Med Chem. 2006. PMID: 16213731

7

Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy.

Yoon KJ, Qi J, Remack JS, Virga KG, Hatfield MJ, Potter PM, Lee RE, Danks MK. Yoon KJ, et al. Among authors: lee re. Mol Cancer Ther. 2006 Jun;5(6):1577-84. doi: 10.1158/1535-7163.MCT-06-0090. Mol Cancer Ther. 2006. PMID: 16818517

8

Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.

Lu YJ, Zhang YM, Grimes KD, Qi J, Lee RE, Rock CO. Lu YJ, et al. Among authors: lee re. Mol Cell. 2006 Sep 1;23(5):765-72. doi: 10.1016/j.molcel.2006.06.030. Mol Cell. 2006. PMID: 16949372 Free article.

9

Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase.

Lu YJ, Zhang F, Grimes KD, Lee RE, Rock CO. Lu YJ, et al. Among authors: lee re. J Biol Chem. 2007 Apr 13;282(15):11339-46. doi: 10.1074/jbc.M700374200. Epub 2007 Feb 16. J Biol Chem. 2007. PMID: 17308305 Free article.

10

Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.

Grimes KD, Lu YJ, Zhang YM, Luna VA, Hurdle JG, Carson EI, Qi J, Kudrimoti S, Rock CO, Lee RE. Grimes KD, et al. Among authors: lee re. ChemMedChem. 2008 Dec;3(12):1936-45. doi: 10.1002/cmdc.200800218. ChemMedChem. 2008. PMID: 19016283 Free PMC article.

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