Obata F - Search Results

1

Independent occurrence of I2020T mutation in the kinase domain of the leucine rich repeat kinase 2 gene in Japanese and German Parkinson's disease families.

Ohta E, Hasegawa K, Gasser T, Obata F. Ohta E, et al. Among authors: obata f. Neurosci Lett. 2007 Apr 24;417(1):21-3. doi: 10.1016/j.neulet.2007.02.086. Epub 2007 Mar 16. Neurosci Lett. 2007. PMID: 17395370

2

The mouse/human cross-species heterodimer of leucine-rich repeat kinase 2: possible significance in the transgenic model mouse of Parkinson's disease.

Miyajima T, Ohta E, Kawada H, Maekawa T, Obata F. Miyajima T, et al. Among authors: obata f. Neurosci Lett. 2015 Feb 19;588:142-6. doi: 10.1016/j.neulet.2015.01.003. Epub 2015 Jan 3. Neurosci Lett. 2015. PMID: 25562633

3

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

Funayama M, Hasegawa K, Ohta E, Kawashima N, Komiyama M, Kowa H, Tsuji S, Obata F. Funayama M, et al. Among authors: obata f. Ann Neurol. 2005 Jun;57(6):918-21. doi: 10.1002/ana.20484. Ann Neurol. 2005. PMID: 15880653

4

I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.

Ohta E, Katayama Y, Kawakami F, Yamamoto M, Tajima K, Maekawa T, Iida N, Hattori S, Obata F. Ohta E, et al. Among authors: obata f. Biochem Biophys Res Commun. 2009 Dec 18;390(3):710-5. doi: 10.1016/j.bbrc.2009.10.034. Epub 2009 Oct 13. Biochem Biophys Res Commun. 2009. PMID: 19833102

5

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.

Ohta E, Kubo M, Obata F. Ohta E, et al. Among authors: obata f. Biochem Biophys Res Commun. 2010 Jan 1;391(1):242-7. doi: 10.1016/j.bbrc.2009.11.043. Epub 2009 Nov 11. Biochem Biophys Res Commun. 2010. PMID: 19912990

6

Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.

Maekawa T, Kubo M, Yokoyama I, Ohta E, Obata F. Maekawa T, et al. Among authors: obata f. Biochem Biophys Res Commun. 2010 Feb 12;392(3):431-5. doi: 10.1016/j.bbrc.2010.01.041. Epub 2010 Jan 15. Biochem Biophys Res Commun. 2010. PMID: 20079710

7

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.

Ohta E, Kawakami F, Kubo M, Obata F. Ohta E, et al. Among authors: obata f. FEBS Lett. 2011 Jul 21;585(14):2165-70. doi: 10.1016/j.febslet.2011.05.044. Epub 2011 Jun 2. FEBS Lett. 2011. PMID: 21658387 Free article.

8

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities.

Maekawa T, Mori S, Sasaki Y, Miyajima T, Azuma S, Ohta E, Obata F. Maekawa T, et al. Among authors: obata f. Mol Neurodegener. 2012 Apr 25;7:15. doi: 10.1186/1750-1326-7-15. Mol Neurodegener. 2012. PMID: 22534020 Free PMC article.

9

Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation.

Ohta E, Kawakami F, Kubo M, Obata F. Ohta E, et al. Among authors: obata f. Biochem Biophys Res Commun. 2013 Jan 11;430(2):560-6. doi: 10.1016/j.bbrc.2012.11.113. Epub 2012 Dec 7. Biochem Biophys Res Commun. 2013. PMID: 23220480

10

Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson's disease carrying the I2020T mutation in LRRK2.

Ohta E, Sone T, Ukai H, Hisamatsu T, Kitagawa T, Ishikawa M, Nagai M, Ueda HR, Obata F, Okano H. Ohta E, et al. Among authors: obata f. Stem Cell Res. 2020 Dec;49:102073. doi: 10.1016/j.scr.2020.102073. Epub 2020 Nov 3. Stem Cell Res. 2020. PMID: 33181472 Free article.

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