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The Cholesterol Metabolite 27HC Increases Secretion of Extracellular Vesicles Which Promote Breast Cancer Progression.
Baek AE, Krawczynska N, Das Gupta A, Dvoretskiy SV, You S, Park J, Deng YH, Sorrells JE, Smith BP, Ma L, Nelson AT, McDowell HB, Sprenger A, Henn MA, Madak-Erdogan Z, Kong H, Boppart SA, Boppart MD, Nelson ER. Baek AE, et al. Endocrinology. 2021 Jul 1;162(7):bqab095. doi: 10.1210/endocr/bqab095. Endocrinology. 2021. PMID: 33959755 Free PMC article.
Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer.
Hutchinson SA, Websdale A, Cioccoloni G, Røberg-Larsen H, Lianto P, Kim B, Rose A, Soteriou C, Pramanik A, Wastall LM, Williams BJ, Henn MA, Chen JJ, Ma L, Moore JB, Nelson E, Hughes TA, Thorne JL. Hutchinson SA, et al. Among authors: henn ma. Oncogene. 2021 Apr;40(16):2872-2883. doi: 10.1038/s41388-021-01720-w. Epub 2021 Mar 19. Oncogene. 2021. PMID: 33742124 Free PMC article.
A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
Boudreau MW, Duraki D, Wang L, Mao C, Kim JE, Henn MA, Tang B, Fanning SW, Kiefer J, Tarasow TM, Bruckheimer EM, Moreno R, Mousses S, Greene GL, Roy EJ, Park BH, Fan TM, Nelson ER, Hergenrother PJ, Shapiro DJ. Boudreau MW, et al. Among authors: henn ma. Sci Transl Med. 2021 Jul 21;13(603):eabf1383. doi: 10.1126/scitranslmed.abf1383. Sci Transl Med. 2021. PMID: 34290053 Free PMC article.
The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple- negative breast cancer.
Nelczyk AT, Ma L, Gupta AD, Gamage HEV, McHenry MT, Henn MA, Kadiri M, Wang Y, Krawczynska N, Bendre S, He S, Shahoei SH, Madak-Erdogan Z, Hsiao SH, Saleh T, Carpenter V, Gewirtz DA, Spinella MJ, Nelson ER. Nelczyk AT, et al. Among authors: henn ma. Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166515. doi: 10.1016/j.bbadis.2022.166515. Epub 2022 Aug 4. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35932893 Free PMC article.
216 results