Isenman DE - Search Results

1

Covalent binding of C3b to C4b within the classical complement pathway C5 convertase. Determination of amino acid residues involved in ester linkage formation.

Kim YU, Carroll MC, Isenman DE, Nonaka M, Pramoonjago P, Takeda J, Inoue K, Kinoshita T. Kim YU, et al. Among authors: isenman de. J Biol Chem. 1992 Feb 25;267(6):4171-6. J Biol Chem. 1992. PMID: 1740458 Free article.

2

A single arginine to tryptophan interchange at beta-chain residue 458 of human complement component C4 accounts for the defect in classical pathway C5 convertase activity of allotype C4A6. Implications for the location of a C5 binding site in C4.

Ebanks RO, Jaikaran AS, Carroll MC, Anderson MJ, Campbell RD, Isenman DE. Ebanks RO, et al. Among authors: isenman de. J Immunol. 1992 May 1;148(9):2803-11. J Immunol. 1992. PMID: 1573269

3

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

Carroll MC, Fathallah DM, Bergamaschini L, Alicot EM, Isenman DE. Carroll MC, et al. Among authors: isenman de. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6868-72. doi: 10.1073/pnas.87.17.6868. Proc Natl Acad Sci U S A. 1990. PMID: 2395880 Free PMC article.

4

Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact.

Pryzdial EL, Isenman DE. Pryzdial EL, et al. Among authors: isenman de. J Biol Chem. 1987 Feb 5;262(4):1519-25. J Biol Chem. 1987. PMID: 3643213 Free article.

5

Regulation of humoral immunity by complement.

Carroll MC, Isenman DE. Carroll MC, et al. Among authors: isenman de. Immunity. 2012 Aug 24;37(2):199-207. doi: 10.1016/j.immuni.2012.08.002. Immunity. 2012. PMID: 22921118 Free PMC article. Review.

6

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome.

Lehtinen MJ, Rops AL, Isenman DE, van der Vlag J, Jokiranta TS. Lehtinen MJ, et al. Among authors: isenman de. J Biol Chem. 2009 Jun 5;284(23):15650-8. doi: 10.1074/jbc.M900814200. Epub 2009 Apr 7. J Biol Chem. 2009. PMID: 19351878 Free PMC article.

7

A thermodynamic study of the interaction between human complement components C3b or C3(H2O) and factor B in solution.

Pryzdial EL, Isenman DE. Pryzdial EL, et al. Among authors: isenman de. J Biol Chem. 1988 Feb 5;263(4):1733-8. J Biol Chem. 1988. PMID: 3338992 Free article.

8

Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3.

Isaac L, Isenman DE. Isaac L, et al. Among authors: isenman de. J Biol Chem. 1992 May 15;267(14):10062-9. J Biol Chem. 1992. PMID: 1577777 Free article.

9

Mutagenesis of the Arg-Gly-Asp triplet in human complement component C3 does not abolish binding of iC3b to the leukocyte integrin complement receptor type III (CR3, CD11b/CD18).

Taniguchi-Sidle A, Isenman DE. Taniguchi-Sidle A, et al. Among authors: isenman de. J Biol Chem. 1992 Jan 5;267(1):635-43. J Biol Chem. 1992. PMID: 1730624 Free article.

10

Mouse complement component C4 is devoid of classical pathway C5 convertase subunit activity.

Ebanks RO, Isenman DE. Ebanks RO, et al. Among authors: isenman de. Mol Immunol. 1996 Feb;33(3):297-309. doi: 10.1016/0161-5890(95)00135-2. Mol Immunol. 1996. PMID: 8649451

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