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The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice.
Russo R, Loverme J, La Rana G, Compton TR, Parrott J, Duranti A, Tontini A, Mor M, Tarzia G, Calignano A, Piomelli D. Russo R, et al. Among authors: tontini a. J Pharmacol Exp Ther. 2007 Jul;322(1):236-42. doi: 10.1124/jpet.107.119941. Epub 2007 Apr 5. J Pharmacol Exp Ther. 2007. PMID: 17412883
Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.
Moreno-Sanz G, Duranti A, Melzig L, Fiorelli C, Ruda GF, Colombano G, Mestichelli P, Sanchini S, Tontini A, Mor M, Bandiera T, Scarpelli R, Tarzia G, Piomelli D. Moreno-Sanz G, et al. Among authors: tontini a. J Med Chem. 2013 Jul 25;56(14):5917-30. doi: 10.1021/jm4007017. Epub 2013 Jul 3. J Med Chem. 2013. PMID: 23822179 Free PMC article.
Modulation of anxiety through blockade of anandamide hydrolysis.
Kathuria S, Gaetani S, Fegley D, Valiño F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D. Kathuria S, et al. Among authors: tontini a. Nat Med. 2003 Jan;9(1):76-81. doi: 10.1038/nm803. Epub 2002 Dec 2. Nat Med. 2003. PMID: 12461523
Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies.
Mor M, Rivara S, Lodola A, Plazzi PV, Tarzia G, Duranti A, Tontini A, Piersanti G, Kathuria S, Piomelli D. Mor M, et al. Among authors: tontini a. J Med Chem. 2004 Oct 7;47(21):4998-5008. doi: 10.1021/jm031140x. J Med Chem. 2004. PMID: 15456244 Free article.
Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).
Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D. Piomelli D, et al. Among authors: tontini a. CNS Drug Rev. 2006 Spring;12(1):21-38. doi: 10.1111/j.1527-3458.2006.00021.x. CNS Drug Rev. 2006. PMID: 16834756 Free PMC article. Review.
48 results