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Page 1
Role of PDX-1 and MafA as a potential therapeutic target for diabetes.
Kaneto H, Miyatsuka T, Fujitani Y, Noguchi H, Song KH, Yoon KH, Matsuoka TA. Kaneto H, et al. Among authors: noguchi h. Diabetes Res Clin Pract. 2007 Sep;77 Suppl 1:S127-37. doi: 10.1016/j.diabres.2007.01.046. Epub 2007 Apr 20. Diabetes Res Clin Pract. 2007. PMID: 17449132 Review.
Mechanism of PDX-1 protein transduction.
Noguchi H, Matsushita M, Matsumoto S, Lu YF, Matsui H, Bonner-Weir S. Noguchi H, et al. Biochem Biophys Res Commun. 2005 Jun 24;332(1):68-74. doi: 10.1016/j.bbrc.2005.04.092. Biochem Biophys Res Commun. 2005. PMID: 15896300
PDX-1 protein is internalized by lipid raft-dependent macropinocytosis.
Noguchi H, Matsumoto S, Okitsu T, Iwanaga Y, Yonekawa Y, Nagata H, Matsushita M, Wei FY, Matsui H, Minami K, Seino S, Masui Y, Futaki S, Tanaka K. Noguchi H, et al. Cell Transplant. 2005;14(9):637-45. doi: 10.3727/000000005783982648. Cell Transplant. 2005. PMID: 16405074 Free article.
A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.
Sassa M, Fukuda K, Fujimoto S, Toyoda K, Fujita Y, Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Ohara T, Okamoto M, Tanaka K, Seino Y, Inagaki N, Yamada Y. Sassa M, et al. Among authors: noguchi h. Diabetes Res Clin Pract. 2006 Sep;73(3):235-40. doi: 10.1016/j.diabres.2006.01.012. Epub 2006 Apr 5. Diabetes Res Clin Pract. 2006. PMID: 16600414 Clinical Trial.
Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.
Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Chen Y, Yuasa T, Tanaka K, Narushima M, Miki A, Misawa H, Tabata Y, Jun HS, Matsumoto S, Fox IJ, Tanaka N, Kobayashi N. Rivas-Carrillo JD, et al. Among authors: noguchi h. Diabetes. 2007 May;56(5):1259-67. doi: 10.2337/db06-1679. Epub 2007 Feb 7. Diabetes. 2007. PMID: 17287463
A human beta-cell line for transplantation therapy to control type 1 diabetes.
Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW. Narushima M, et al. Among authors: noguchi h. Nat Biotechnol. 2005 Oct;23(10):1274-82. doi: 10.1038/nbt1145. Epub 2005 Sep 25. Nat Biotechnol. 2005. PMID: 16186810
2,073 results