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Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN. Kienlen-Campard P, et al. Among authors: courtoy pj. J Biol Chem. 2008 Mar 21;283(12):7733-44. doi: 10.1074/jbc.M707142200. Epub 2008 Jan 16. J Biol Chem. 2008. PMID: 18201969 Free PMC article.
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.
Pierrot N, Tyteca D, D'auria L, Dewachter I, Gailly P, Hendrickx A, Tasiaux B, Haylani LE, Muls N, N'kuli F, Laquerrière A, Demoulin JB, Campion D, Brion JP, Courtoy PJ, Kienlen-Campard P, Octave JN. Pierrot N, et al. Among authors: courtoy pj. EMBO Mol Med. 2013 Apr;5(4):608-25. doi: 10.1002/emmm.201202215. EMBO Mol Med. 2013. PMID: 23554170 Free PMC article.
211 results